Who We Are

The Ley lab studies atherosclerosis, the pathomechanism underlying most cardiovascular disease. We focus on the adaptive immune system. We work on the autoimmune aspect of atherosclerosis, mainly on the CD4 and CD8 T cell responses.


Dr. Klaus Ley

 

 

Klaus Ley, M.D.

Founding Co-Director, Immunology Center of Georgia (IMMCG)
Georgia Research Alliance Bradley Turner Eminent Scholar in Immunology
Professor, Department of Physiology
Medical College of Georgia at Augusta University

 

 

What We Study

The lab uses human samples from patients with the disease we study: cardiovascular disease including coronary artery disease. Major methods we use:

  • Human blood leukocytes: single cell RNA sequencing with surface phenotype by CITE-Seq
  • Spectral flow cytometry
  • Bioinformatics: noise reduction methods, gene signatures
  • T cell receptor sequencing
  • Epitope identification
  • Cell type discovery
  • Lineage tracker mice
  • Reporter mice
  • Knockout and knockin mice
  • Intravital microscopy

Contact Us

Immunology Center of Georgia (IMMCG)

Health Sciences Campus

Georgia Cancer Center - M. Bert Storey Research Building

1410 Laney Walker Blvd, CN2119

kley@augusta.edu

706-446-0296

Research Team

photo of Michael Nakama, MS

Michael Nakama, MS

  • Research Manager

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United States of America

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Pei Xiong Liew

  • Senior Research Scientist

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Singapore

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Mikhail Fomin, MSc

  • Research Associate

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United States of America

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Payel Roy, PhD

  • Assistant Research Scientist

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 India

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China

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Mohammad Oliaeimotlagh, MD MSc

  • Postdoc

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Iran

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Amir Khan, PhD

  • Postdoc

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Pakistan

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Smriti Parashar, PhD

  • Postdoc

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 India

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Sunil Kumar, Ph.D.

  • Postdoc

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 India

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Yan Wang, PhD

  • Postdoc

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China

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Megh Mehta

  • Graduate Research Assistant

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United States of America

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Aderonke Fakoyade

  • Graduate Research Assistant

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Current Research Interests

  • High-dimensional data generated by single-cell RNA sequencing
  • Integrin activation in immune cells
  • Autoimmune response to ApoB and the potential to apply this to develop a vaccine for atherosclerosis
  • Understanding a newly discovered type of olfactory receptors in macrophages and their role in atherosclerosis
  • Understanding differences in the immune response of diverse populations to atherosclerosis