Vijay Ganta - Research & Publications

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Research Interests

My lab studies the molecular processes that regulate ischemic angiogenesis in cardiovascular diseases. We use RNA/DNA sequencing, metabolomics, and bioinformatics analysis to discover novel genetic and metabolic regulators of ischemic angiogenic programs. Insights from these studies will be used to target and regulate endothelial and macrophage phenotypes in in-vitro and in-vivo pre-clinical models and test their ability to revascularize the ischemic tissue for optimal blood flow and perfusion.

 

 

Research Projects

My lab is interested in understanding the molecular mechanisms that regulate angiogenesis in hypoxic tissue environment.

Current studies focus on understanding and targeting the

1. Metabolic shifts in hypoxic endothelial cells that regulate their angiogenic capacity to revascularize ischemic tissue. This project studies the role of glycolytic vs. non-glycolytic metabolic pathways that regulate hypoxic endothelial angiogenic capacity in Peripheral Artery Disease (PAD).
2. Non-coding RNAs that regulate hypoxic endothelial and macrophage phenotypes to enhance microvascular perfusion. Novel Non-coding RNAs (small and long) discovered from PAD patients segregated based on disease severity will be tested for their translational potential in regulating endothelial and macrophage phenotypes using in-vitro and in-vivo models of Preclinical PAD.
3. Splicing mechanisms that produce alternatively spliced anti-angiogenic VEGF-A isoforms in PAD. Molecular processes and signaling events that regulate VEGF-A splicing to produce of Pro- vs. Anti-angiogenic VEGF-A isoforms in ischemic vasculature is the focus of the study.

 

 

 

Spotlight Publications

 

Vijay Chaitanya Ganta*, Min Choi, Charles Farber, Brian Annex. Anti-angiogenic VEGF165b regulates Macrophage-polarization via S100A8/S100A9 in Peripheral Artery Disease. Circulation. 2018; 139:226–242. 2019 Jan 8;139(2):226-242

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.034165

Ganta VC, Choi MH, Kutateladze A, Fox TE, Farber CR, Annex BH. A MicroRNA93-Interferon Regulatory Factor-9-Immunoresponsive Gene-1-Itaconic Acid Pathway Modulates M2-Like macrophage Polarization to Revascularize Ischemic Muscle. Circulation. 2017; 135(24):2403-2425.

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.116.025490

Ganta VC, Choi M, Kutateladze A, Annex BH. VEGF165b Modulates Endothelial VEGFR1-STAT3 Signaling Pathway and Angiogenesis in Human and Experimental Peripheral Arterial Disease. Circulation Research. 2017; 120(2):282-295.

https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.116.309516

 

 

 

Recent Publications

 

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