706-721-7742
dmattson@augusta.edu
Office: CA-3096 | Lab: CA:3097
706-721-7299
Lab Personnel
Emily Burns
John Henry Dasinger, PhD
Mary Shaw
Sam Walton
EducationAcademic AppointmentsResearch InterestsAwards & HonorsPublications
University of Minnesota-Duluth, Biology, BS, 1984
Medical College of Wisconsin, Physiology, PhD, 1990
Department Chair and Professor, Department of Physiology, Medical College of Georgia, Augusta University
Professor with Tenure, Medical College of Wisconsin
Interim Senior Associate Dean of Research, Medical College of Wisconsin
Associate Professor, Medical College of Wisconsin
Assistant Professor, Medical College of Wisconsin
Studies in the Mattson laboratory examine the normal and pathophysiological regulation of renal function and arterial blood pressure. A particular emphasis is placed on the paracrine, autocrine, and hormonal regulation of renal tubular and vascular function. Additional studies are geared toward an understanding of the genetic basis of hypertension and renal disease. The work performed in my laboratory utilizes techniques taken from molecular biology, biochemistry, immunology, and integrative physiology to address the role of the kidney in the regulation of sodium and water homeostasis and arterial pressure. Studies utilize in vitro measurements of mRNA, protein, enzymatic activity, enzyme kinetics, and cell signaling as well as in vivo measurements of hormone levels, blood flow, blood pressure, and other indices of renal/cardiovascular function in anesthetized and conscious rats and mice. Our experimental models include various strains of inbred and genetically manipulated rats and mice.
Outstanding Dissertation Award, Medical College of Wisconsin
Merck Sharpe & Dohme Travel Fellowship
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Impact of Hematopoietic CD14 on Oxidative Stress during Salt-Sensitive Hypertension and Kidney InjuryBurns-Ray, E. C., Dasinger, J. H., Cherian-Shaw, M., Walton, S. D., Baldwin, K. E., Cormier, A. B., Hasan, S., Fehrenbach, D. J., Abais-Battad, J. M. & Mattson, D. L., 2025, (Accepted/In press) In: Journal of the American Society of Nephrology. 10.1681/ASN.0000000717.Research output: Contribution to journal › Article › peer-review |
Renal Medulla in HypertensionCowley, A. W., Roman, R. J., Mattson, D. L., Franchini, K. G., O’Connor, P. M., Makino, A., Taylor, N. E., Evans, L. C., Mori, T., Dickhout, J. G., Jin, C., Miyata, N., Nakanishi, K., Szentiványi, M., Park, F., Skelton, M. M., Kurth, T. & Shimada, S., Dec 1 2024, In: Hypertension. 81, 12, p. 2383-2394 12 p.Research output: Contribution to journal › Review article › peer-review |
Intact NOX2 in T Cells Mediates Pregnancy-Induced Renal Damage in Dahl SS RatsDasinger, J. H., Abais-Battad, J. M., Walton, S. D., Burns-Ray, E. C., Cherian-Shaw, M., Baldwin, K. E., Fehrenbach, D. J. & Mattson, D. L., Nov 1 2024, In: Hypertension. 81, 11, p. 2357-2367 11 p.Research output: Contribution to journal › Article › peer-review |
Sex-Dependency of T Cell-Induced Salt-Sensitive Hypertension and Kidney DamageAbais-Battad, J. M., Dasinger, J. H., Lund, H., Burns-Ray, E. C., Walton, S. D., Baldwin, K. E., Fehrenbach, D. J., Cherian-Shaw, M. & Mattson, D. L., Jul 1 2024, In: Hypertension. 81, 7, p. 1511-1523 13 p.Research output: Contribution to journal › Article › peer-review |
Functional NADPH oxidase 2 in T cells amplifies salt-sensitive hypertension and associated renal damageWalton, S. D., Dasinger, J. H., Burns, E. C., Cherian-Shaw, M., Abais-Battad, J. M. & Mattson, D. L., Aug 2023, In: American Journal of Physiology - Renal Physiology. 325, 2, p. F214-F223Research output: Contribution to journal › Article › peer-review |
Dietary Protein, Chronic Salt-Sensitive Hypertension, and Kidney DamageMattson, D. L., Dasinger, J. H. & Abais-Battad, J. M., Aug 1 2023, In: Kidney360. 4, 8, p. 1181-1187 7 p.Research output: Contribution to journal › Review article › peer-review |
E-value: a superior alternative to P-value and its adjustments in DNA methylation studiesYang, Y., Liu, H., Liu, Y., Zhou, L., Zheng, X., Yue, R., Mattson, D. L., Kidambi, S., Liang, M., Liu, P. & Pan, X., Jul 1 2023, In: Briefings in Bioinformatics. 24, 4, bbad241.Research output: Contribution to journal › Article › peer-review |
Renal histaminergic system and acute effects of histamine receptor 2 blockade on renal damage in the Dahl salt-sensitive ratSpires, D. R., Schibalski, R. S., Domondon, M., Clarke, C., Perez, S., Anwar, F., Burns, E., Saeed, M. I., Walton, S. D., Zamaro, A. S., Amoah, T., Arkhipov, S. N., Christopher, C. J., Campagna, S. R., Mattson, D. L., Pavlov, T. S. & Ilatovskaya, D. V., Jul 2023, In: American Journal of Physiology - Renal Physiology. 325, 1, p. F105-F120Research output: Contribution to journal › Article › peer-review |
Correction:T Cells Contribute to Pathological Responses in the Non-Targeted Rat Heart following Irradiation of the Kidneys(Toxics, (2022), 10, (797), 10.3390/toxics10120797)Lenarczyk, M., Alsheikh, A. J., Cohen, E. P., Schaue, D., Kronenberg, A., Geurts, A., Klawikowski, S., Mattson, D. & Baker, J. E., Feb 2023, In: Toxics. 11, 2, 183.Research output: Contribution to journal › Comment/debate › peer-review |
Impact of bedding on Dahl salt-sensitive hypertension and renal damageDasinger, J. H., Walton, S. D., Burns, E. C., Cherian-Shaw, M., Abais-Battad, J. M. & Mattson, D. L., Dec 2022, In: American Journal of Physiology - Renal Physiology. 323, 6, p. F666-F672Research output: Contribution to journal › Article › peer-review |
Gut-Immune-Kidney Axis: Influence of Dietary Protein in Salt-Sensitive HypertensionMattson, D. L., Dasinger, J. H. & Abais-Battad, J. M., Nov 1 2022, In: Hypertension. 79, 11, p. 2397-2408 12 p.Research output: Contribution to journal › Review article › peer-review |
Lymphatics and Blood PressureMattson, D. L., Nov 1 2022, In: Hypertension. 79, 11, p. 2463-2464 2 p.Research output: Contribution to journal › Editorial › peer-review |
Acute Increase of Renal Perfusion Pressure Causes Rapid Activation of mTORC1 (Mechanistic Target Of Rapamycin Complex 1) and Leukocyte InfiltrationShimada, S., Yang, C., Kumar, V., Mattson, D. L. & Cowley, A. W., Jun 1 2022, In: Hypertension. 79, 6, p. 1180-1189 10 p.Research output: Contribution to journal › Article › peer-review |
Unique Associations of DNA Methylation Regions with 24-Hour Blood Pressure Phenotypes in BlacksRoberts, M. L., Kotchen, T. A., Pan, X., Li, Y., Yang, C., Liu, P., Wang, T., Laud, P. W., Chelius, T. H., Munyura, Y., Mattson, D. L., Liu, Y., Cowley, A. W., Kidambi, S. & Liang, M., Apr 1 2022, In: Hypertension. 79, 4, p. 761-772 12 p.Research output: Contribution to journal › Article › peer-review |
Inflammatory macrophages in the kidney contribute to salt-sensitive hypertensionFehrenbach, D. J. & Mattson, D. L., Mar 2022, In: American Journal of Physiology - Renal Physiology. 318, 3, p. F544-F548Research output: Contribution to journal › Review article › peer-review |
T Cell Immunometabolism and Redox Signaling in HypertensionMattson, D. L. & Abais-Battad, J. M., Dec 2021, In: Current Hypertension Reports. 23, 12, 45.Research output: Contribution to journal › Review article › peer-review |
p66Shc-mediated hydrogen peroxide production impairs nephrogenesis causing reduction of number of glomeruliMiller, B., Palygin, O., El-Meanawy, A., Mattson, D. L., Geurts, A. M., Staruschenko, A. & Sorokin, A., Aug 15 2021, In: Life sciences. 279, 119661.Research output: Contribution to journal › Article › peer-review |
Dietary influences on the Dahl SS rat gut microbiota and its effects on salt-sensitive hypertension and renal damageAbais-Battad, J. M., Saravia, F. L., Lund, H., Dasinger, J. H., Fehrenbach, D. J., Alsheikh, A. J., Zemaj, J., Kirby, J. R. & Mattson, D. L., Aug 2021, In: Acta Physiologica. 232, 4, e13662.Research output: Contribution to journal › Article › peer-review |
Dietary Sodium Restriction Results in Tissue-Specific Changes in DNA Methylation in HumansKidambi, S., Pan, X., Yang, C., Liu, P., Roberts, M. L., Li, Y., Wang, T., Laud, P. W., Liu, Y., Rubens, M., Thomas, R., Widlansky, M. E., Beyer, A. M., Liu, Y., Cowley, A. W., Kotchen, T. A., Munyura, Y., Moosreiner, A., Mattson, D. L. & Liang, M., Aug 1 2021, In: Hypertension. 78, 2, p. 434-446 13 p.Research output: Contribution to journal › Article › peer-review |
Dietary protein source contributes to the risk of developing maternal syndrome in the Dahl salt-sensitive ratDasinger, J. H., Abais-Battad, J. M., Bukowy, J. D., Lund, H., Alsheikh, A. J., Fehrenbach, D. J., Zemaj, J. & Mattson, D. L., Jun 2021, In: Pregnancy Hypertension. 24, p. 126-134 9 p.Research output: Contribution to journal › Article › peer-review |
Team Science: American Heart Association's Hypertension Strategically Focused Research Network ExperienceSantillan, M. K., Becker, R. C., Calhoun, D. A., Cowley, A. W., Flynn, J. T., Grobe, J. L., Kotchen, T. A., Lackland, D. T., Leslie, K. K., Liang, M., Mattson, D. L., Meyers, K. E., Mitsnefes, M. M., Muntner, P. M., Pierce, G. L., Pollock, J. S., Sigmund, C. D., Thomas, S. J., Urbina, E. M. & Kidambi, S., Jun 1 2021, In: Hypertension. 77, 6, p. 1857-1866 10 p.Research output: Contribution to journal › Review article › peer-review |
Make a difference—get involvedMattson, D., May 2021, Physiologist, 64, 3, p. 36-37 2 p.Research output: Contribution to specialist publication › Article |
Contribution of Th17 cells to tissue injury in hypertensionBasile, D. P., Abais-Battad, J. M. & Mattson, D. L., Mar 2021, In: Current opinion in nephrology and hypertension. 30, 2, p. 151-158 8 p.Research output: Contribution to journal › Review article › peer-review |
Sexual Dimorphic Role of CD14 (Cluster of Differentiation 14) in Salt-Sensitive Hypertension and Renal InjuryFehrenbach, D. J., Abais-Battad, J. M., Dasinger, J. H., Lund, H., Keppel, T., Zemaj, J., Cherian-Shaw, M., Gundry, R. L., Geurts, A. M., Dwinell, M. R. & Mattson, D. L., Jan 1 2021, In: Hypertension. 77, 1, p. 228-240 13 p.Research output: Contribution to journal › Article › peer-review |
Amplification of Salt-Sensitive Hypertension and Kidney Damage by Immune MechanismsMattson, D. L., Dasinger, J. H. & Abais-Battad, J. M., Jan 1 2021, In: American journal of hypertension. 34, 1, p. 3-14 12 p.Research output: Contribution to journal › Review article › peer-review |
Twenty-four-hour versus clinic blood pressure levels as predictors of long-term cardiovascular and renal disease outcomes among African AmericansKidambi, S., Wang, T., Chelius, T., Nunuk, I., Agarwal, P., Laud, P., Mattson, D., Cowley, A. W., Liang, M. & Kotchen, T., Dec 1 2020, In: Scientific reports. 10, 1, 11685.Research output: Contribution to journal › Article › peer-review |
Irradiation of the kidneys causes pathologic remodeling in the nontargeted heart: A role for the immune systemLenarczyk, M., Laiakis, E. C., Mattson, D. L., Johnson, B. D., Kronenberg, A., North, P. E., Komorowski, R., Mäder, M. & Baker, J. E., Dec 2020, In: FASEB BioAdvances. 2, 12, p. 705-719 15 p.Research output: Contribution to journal › Article › peer-review |
Renal Perfusion Pressure Determines Infiltration of Leukocytes in the Kidney of Rats with Angiotensin II-Induced HypertensionShimada, S., Abais-Battad, J. M., Alsheikh, A. J., Yang, C., Stumpf, M., Kurth, T., Mattson, D. L. & Cowley, A. W., Sep 1 2020, In: Hypertension. 76, 3, p. 849-858 10 p.Research output: Contribution to journal › Article › peer-review |
Influences of environmental factors during preeclampsiaDasinger, J. H., Abais-Battad, J. M. & Mattson, D. L., Jul 2020, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 319, 1, p. R26-R32Research output: Contribution to journal › Review article › peer-review |
Splenocyte transfer exacerbates salt-sensitive hypertension in ratsFehrenbach, D. J., Dasinger, J. H., Lund, H., Zemaj, J. & Mattson, D. L., May 1 2020, In: Experimental Physiology. 105, 5, p. 864-875 12 p.Research output: Contribution to journal › Article › peer-review |
CCL2 mediates early renal leukocyte infiltration during salt-sensitive hypertensionAlsheikh, A. J., Dasinger, J. H., Abais-Battad, J. M., Fehrenbach, D. J., Yang, C., Cowley, A. W. & Mattson, D. L., Apr 2020, In: American Journal of Physiology - Renal Physiology. 318, 4, p. F982-F993Research output: Contribution to journal › Article › peer-review |
Dietary Effects on Dahl Salt-Sensitive Hypertension, Renal Damage, and the T Lymphocyte TranscriptomeAbais-Battad, J. M., Alsheikh, A. J., Pan, X., Fehrenbach, D. J., Dasinger, J. H., Lund, H., Roberts, M. L., Kriegel, A. J., Cowley, A. W., Kidambi, S., Kotchen, T. A., Liu, P., Liang, M. & Mattson, D. L., Oct 1 2019, In: Hypertension. 74, 4, p. 854-863 10 p.Research output: Contribution to journal › Article › peer-review |
Animal Models of Hypertension: A Scientific Statement From the American Heart AssociationLerman, L. O., Kurtz, T. W., Touyz, R. M., Ellison, D. H., Chade, A. R., Crowley, S. D., Mattson, D. L., Mullins, J. J., Osborn, J., Eirin, A., Reckelhoff, J. F., Iadecola, C. & Coffman, T. M., Jun 1 2019, In: Hypertension (Dallas, Tex. : 1979). 73, 6, p. e87-e120Research output: Contribution to journal › Review article › peer-review |
Rag1-null dahl ss rats reveal that adaptive immune mechanisms exacerbate high protein-induced hypertension and renal injuryAbais-Battad, J. M., Lund, H., Fehrenbach, D. J., Dasinger, J. H. & Mattson, D. L., Jul 2 2018, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 315, 1, p. R28-R35,Research output: Contribution to journal › Article › peer-review |
p66Shc regulates renal vascular tone in Hypertension-induced nephropathyMiller, B., Palygin, O., Rufanova, V. A., Chong, A., Lazar, J., Jacob, H. J., Mattson, D., Roman, R. J., Williams, J. M., Cowley, A. W., Geurts, A. M., Staruschenko, A., Imig, J. D. & Sorokin, A., Jul 1 2016, In: Journal of Clinical Investigation. 126, 7, p. 2533-2546 14 p.Research output: Contribution to journal › Article › peer-review |
Role of immune cells in salt-sensitive hypertension and renal injuryWade, B., Abais-Battad, J. M. & Mattson, D. L., Jan 1 2016, In: Current opinion in nephrology and hypertension. 25, 1, p. 22-27 6 p.Research output: Contribution to journal › Review article › peer-review |
Inflammation and Hypertension: New Understandings and Potential Therapeutic TargetsDe Miguel, C., Rudemiller, N. P., Abais, J. M. & Mattson, D. L., 2015, In: Current Hypertension Reports. 17, 1Research output: Contribution to journal › Review article › peer-review |
CD247 modulates blood pressure by altering t-lymphocyte infiltration in the kidneyRudemiller, N., Lund, H., Jacob, H. J., Geurts, A. M. & Mattson, D. L., Mar 2014, In: Hypertension. 63, 3, p. 559-564 6 p.Research output: Contribution to journal › Article › peer-review |
Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damageMattson, D. L., Lund, H., Guo, C., Rudemiller, N., Geurts, A. M. & Jacob, H., 2013, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 304, 6, p. R407-R414Research output: Contribution to journal › Article › peer-review |
Effector memory T lymphocytes in renal diseaseMattson, D. L., Dec 2010, In: American Journal of Physiology - Renal Physiology. 299, 6, p. F1257Research output: Contribution to journal › Editorial › peer-review |
Hypertension. 2024 Dec;81(12):2383-2394. doi: 10.1161/HYPERTENSIONAHA.124.21711. Epub 2024 Sep 30. PMID: 39344517
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