David L. Mattson, PhD

Georgia Research Alliance Eminent Scholar in Hypertension, Physiology Department Chair

Phone: (706) 721-7742
Fax: (706) 721-7299
Email: dmattson@augusta.edu
Office: CA-3123
Lab: CA-3101

Learn More about Dr. Mattson's Research

Education and Training

University of Minnesota-Duluth, Biology, BS, 1984
Medical College of Wisconsin, Physiology, PhD, 1990

Academic Appointments

1992-1997 - Assistant Professor, Medical College of Wisconsin
1997-2002 - Associate Professor, Medical College of Wisconsin
2014-2015 - Interim Senior Associate Dean of Research, Medical College of Wisconsin
2002-2019 - Professor with Tenure, Medical College of Wisconsin
2019 - Department Chair and Professor, Department of Physiology, Medical College of Georgia, Augusta University

Research Interests

Studies in the Mattson laboratory examine the normal and pathophysiological regulation of renal function and arterial blood pressure. A particular emphasis is placed on the paracrine, autocrine, and hormonal regulation of renal tubular and vascular function. Additional studies are geared toward an understanding of the genetic basis of hypertension and renal disease. The work performed in my laboratory utilizes techniques taken from molecular biology, biochemistry, immunology, and integrative physiology to address the role of the kidney in the regulation of sodium and water homeostasis and arterial pressure. Studies utilize in vitro measurements of mRNA, protein, enzymatic activity, enzyme kinetics, and cell signaling as well as in vivo measurements of hormone levels, blood flow, blood pressure, and other indices of renal/cardiovascular function in anesthetized and conscious rats and mice. Our experimental models include various strains of inbred and genetically manipulated rats and mice.

Awards and Honors

1984             Summa Cum Laude, University of Minnesota Duluth
1990       Outstanding Dissertation Award, Medical College of Wisconsin
1991           Merck Sharpe & Dohme Travel Fellowship
1998           Fellow, American Heart Association Council for High Blood Pressure Research
2000             Established Investigator Award, American Heart Association
2006           Distinguished Lecturer in Integrative Physiology, University of Saskatchewan
2008,10-16 Outstanding Medical Student Educator, Medical College of Wisconsin
2013,18      Medical College of WisconsinFaculty Service Award
2015           Medical College of Wisconsin Distinguished Service Award
2016           Medical College of Wisconsin Society of Teaching Scholars
2018           Starling Award-American Physiological Society

Representative Publications

(Go to Pub Med)

Fehrenbach DJ, Abais-Battad JM, Dasinger JH, Lund H, Keppel, T, Zemaj J, Gundry RL, Geurts AM, Dwinell MR, Mattson DL. Sexual dimorphic role of CD14 in salt sensitive hypertension and renal injury. Hypertension 77:228-240, 2021.
Basile DP, Abais-Battad JM, Mattson DL. Contribution of Th17 cells to tissue injury in hypertension. Current Opinion in Nephrology and Hypertension 30:151-158, 2021.
Mattson DL, Dasinger JH, Abais-Battad JM. Amplification of Salt-Sensitive Hypertension and Kidney Damage by Immune Mechanisms. Am J Hypertension 34:3-14, 2021.
Kidambi S, Wang T, Chelius T, Nunuk I, Agarwal P, Laud P, Mattson D, Cowley AW, Jr., Liang M, Kotchen T. Twenty-four-hour versus clinic blood pressure levels as predictors of long-term cardiovascular and renal disease outcomes among African Americans. Scientific Reports 10:11685, 2020.
Shimada S, Abais-Battad JM, Alsheikh AJ, Yang C, Stumpf M, Kurth T, Mattson DL, Cowley, AW Jr. Renal perfusion pressure determines infiltration of leukocytes in the kidney of rats with angiotensin II induced hypertension. Hypertension 76:849-858, 2020.
Abais-Battad JM, Lund H, Dasinger JH, Fehrenbach DJ, Cowley, A, Mattson DL. NOX2-derived reactive oxygen species in immune cells exacerbates salt-sensitive hypertension. Free Radical Biology & Medicine 146:333-339, 2020.
Dasinger JH, Alsheikh AJ, Abais-Battad JM, Pan X, Fehrenbach DJ, Lund H, Roberts ML, Cowley AW Jr, Kidambi S, Kotchen TA, Liu P, Liang M, Mattson DL. Epigenetic modifications in T cells: the role of DNA methylation in salt-sensitive hypertension. Hypertension 75:372-382, 2020.
Fehrenbach DJ, Mattson DL. Inflammatory macrophages in the kidney contribute to salt-sensitive hypertension. Am J Physiol 318:F544-F548, 2020.
Fehrenbach DJ, Dasinger JH, Lund H, Zemaj J, Mattson DL. Splenocyte transfer exacerbates salt-sensitive hypertension in rats. Exp Physiol 105:864-875, 2020.
Alsheikh AJ, Dasinger JH, Abais-Battad JM, Fehrenbach DJ, Yang C, Cowley AW Jr, Mattson DL. CCL2 mediates early renal leukocyte infiltration during salt-sensitive hypertension. Am J Physiol 318:F982-F993, 2020.
Mattson DL. Immune mechanisms of salt-sensitive hypertension and renal end-organ damage. Nat Rev Nephrol. 2019 May;15(5):290-300.
Abais-Battad JM, Alsheikh AJ, Pan X, Fehrenbach DJ, Dasinger JH, Lund H, Roberts ML, Kriegel AJ, Cowley AW Jr, Kidambi S, Kotchen TA, Liu P, Liang M, Mattson DL. Dietary Effects on Dahl Salt-Sensitive Hypertension, Renal Damage, and the T Lymphocyte Transcriptome. Hypertension. 2019 Oct;74(4):854-863.
Fehrenbach DJ, Abais-Battad JM, Dasinger JH, Lund H, Mattson DL. Salt-sensitive increase in macrophages in the kidneys of Dahl SS rats. Am J Physiol Renal Physiol. 2019 Aug 1;317(2):F361-F374.
Alsheikh AJ, Lund H, Dasinger JH, Abais-Battad JM, Fehrenbach DJ, Mattson DL. Renal nerves and leukocyte infiltration in the kidney during salt-sensitive hypertension. Am J Physiol Regul Integr Comp Physiol. 2019 Jul 1;317(1):R182-R189.
Lerman LO, Kurtz TW, Touyz RM, Ellison DH, Chade AR, Crowley SD, Mattson DL, Mullins JJ, Osborn J, Eirin A, Reckelhoff JF, Iadecola C, Coffman TM. Animal Models of Hypertension: A Scientific Statement From the American Heart Association. Hypertension. 2019 Jun;73(6):e87-e120.
Parental Dietary Protein Source and the Role of CMKLR1 in Determining the Severity of Dahl Salt-Sensitive Hypertension. (Abais-Battad JM, Lund H, Fehrenbach DJ, Dasinger JH, Alsheikh AJ, Mattson DL.) Hypertension. 2019 Feb;73(2):440-448.
Influence of dietary protein on Dahl salt-sensitive hypertension: a potential role for gut microbiota. (Abais-Battad JM, Mattson DL.) Am J Physiol Regul Integr Comp Physiol. 2018 Nov 01;315(5):R907-R914.
Heat stress nephropathy and hyperuricemia. (Mattson DL.) Am J Physiol Renal Physiol. 2018 Oct 01;315(4):F757-F758.
Stability of global methylation profiles of whole blood and extracted DNA under different storage durations and conditions. (Li Y, Pan X, Roberts ML, Liu P, Kotchen TA, Cowley AW Jr, Mattson DL, Liu Y, Liang M, Kidambi S.) Epigenomics. 2018 06;10(6):797-811.
Genetics: An integrated genetic analysis of disease. (Mattson DL.) Nat Rev Nephrol. 2018 May;14(5):287-288.
The complement system in hypertension and renal damage in the Dahl SS rat.(Regal JF, Laule CF, McCutcheon L, Root KM, Lund H, Hashmat S, Mattson DL.) Physiol Rep. 2018 Mar;6(6):e13655.

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