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David Mattson posing and smiling for the camera in his lab.
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  • Faculty | Physiology
  • David L. Mattson, PhD

David L. Mattson, PhD

David L. Mattson, PhD

Physiology Department Chair,

Georgia Research Alliance Eminent Scholar in Hypertension

 

706-721-7742
dmattson@augusta.edu
Office: CA-3096 | Lab: CA:3097
706-721-7299

Dr. Mattson's Faculty Profile

Lab Personnel

Justine Abais-Battad, PhD

  • Instructor

Emily Burns

  • Graduate Student

John Henry Dasinger, PhD

  • Senior Postdoctoral Fellow

Mary Shaw

  • Research Assistant

Sam Walton

  • Graduate Student

EducationAcademic AppointmentsResearch InterestsAwards & HonorsPublications

Education

University of Minnesota-Duluth, Biology, BS, 1984
Medical College of Wisconsin, Physiology, PhD, 1990

Academic Appointments

  • 2019 – Present

Department Chair and Professor, Department of Physiology, Medical College of Georgia, Augusta University

  • 2002-2019

Professor with Tenure, Medical College of Wisconsin

  • 2014-2015

Interim Senior Associate Dean of Research, Medical College of Wisconsin

  • 2017 –2024

 Associate Professor, Medical College of Wisconsin

  • 1992-1997

Assistant Professor, Medical College of Wisconsin

Research Interests

Studies in the Mattson laboratory examine the normal and pathophysiological regulation of renal function and arterial blood pressure. A particular emphasis is placed on the paracrine, autocrine, and hormonal regulation of renal tubular and vascular function. Additional studies are geared toward an understanding of the genetic basis of hypertension and renal disease. The work performed in my laboratory utilizes techniques taken from molecular biology, biochemistry, immunology, and integrative physiology to address the role of the kidney in the regulation of sodium and water homeostasis and arterial pressure. Studies utilize in vitro measurements of mRNA, protein, enzymatic activity, enzyme kinetics, and cell signaling as well as in vivo measurements of hormone levels, blood flow, blood pressure, and other indices of renal/cardiovascular function in anesthetized and conscious rats and mice. Our experimental models include various strains of inbred and genetically manipulated rats and mice. 

Awards & Honors

1984

 Summa Cum Laude, University of Minnesota Duluth

1990

Outstanding Dissertation Award, Medical College of Wisconsin

1991

 Merck Sharpe & Dohme Travel Fellowship

1998

Fellow, American Heart Association Council for High Blood Pressure Research

2000

Established Investigator Award, American Heart Association

2006

Distinguished Lecturer in Integrative Physiology, University of Saskatchewan

2008, 2010-16

Outstanding Medical Student Educator, Medical College of Wisconsin

2013, 2018

Medical College of Wisconsin - Faculty Service Award

2015

Medical College of Wisconsin - Distinguished Service Award

2016

Medical College of Wisconsin Society of Teaching Scholars

2018

Starling Award-American Physiological Society

Publications

Publication
​

Renal Medulla in Hypertension

Cowley, A. W., Roman, R. J., Mattson, D. L., Franchini, K. G., O’Connor, P. M., Makino, A., Taylor, N. E., Evans, L. C., Mori, T., Dickhout, J. G., Jin, C., Miyata, N., Nakanishi, K., Szentiványi, M., Park, F., Skelton, M. M., Kurth, T. & Shimada, S., Dec 1 2024, In: Hypertension. 81, 12, p. 2383-2394 12 p.

Research output: Contribution to journal › Review article › peer-review

​

Intact NOX2 in T Cells Mediates Pregnancy-Induced Renal Damage in Dahl SS Rats

Dasinger, J. H., Abais-Battad, J. M., Walton, S. D., Burns-Ray, E. C., Cherian-Shaw, M., Baldwin, K. E., Fehrenbach, D. J. & Mattson, D. L., Nov 1 2024, In: Hypertension. 81, 11, p. 2357-2367 11 p.

Research output: Contribution to journal › Article › peer-review

​

Sex-Dependency of T Cell-Induced Salt-Sensitive Hypertension and Kidney Damage

Abais-Battad, J. M., Dasinger, J. H., Lund, H., Burns-Ray, E. C., Walton, S. D., Baldwin, K. E., Fehrenbach, D. J., Cherian-Shaw, M. & Mattson, D. L., Jul 1 2024, In: Hypertension. 81, 7, p. 1511-1523 13 p.

Research output: Contribution to journal › Article › peer-review

​

Dietary Protein, Chronic Salt-Sensitive Hypertension, and Kidney Damage

Mattson, D. L., Dasinger, J. H. & Abais-Battad, J. M., Aug 1 2023, In: Kidney360. 4, 8, p. 1181-1187 7 p.

Research output: Contribution to journal › Review article › peer-review

​

E-value: a superior alternative to P-value and its adjustments in DNA methylation studies

Yang, Y., Liu, H., Liu, Y., Zhou, L., Zheng, X., Yue, R., Mattson, D. L., Kidambi, S., Liang, M., Liu, P. & Pan, X., Jul 1 2023, In: Briefings in Bioinformatics. 24, 4, bbad241.

Research output: Contribution to journal › Article › peer-review

​

Functional NADPH oxidase 2 in T cells amplifies salt-sensitive hypertension and associated renal damage

Walton, S. D., Dasinger, J. H., Burns, E. C., Cherian-Shaw, M., Abais-Battad, J. M. & Mattson, D. L., Aug 2023, In: American Journal of Physiology - Renal Physiology. 325, 2, p. F214-F223

Research output: Contribution to journal › Article › peer-review

​

Renal histaminergic system and acute effects of histamine receptor 2 blockade on renal damage in the Dahl salt-sensitive rat

Spires, D. R., Schibalski, R. S., Domondon, M., Clarke, C., Perez, S., Anwar, F., Burns, E., Saeed, M. I., Walton, S. D., Zamaro, A. S., Amoah, T., Arkhipov, S. N., Christopher, C. J., Campagna, S. R., Mattson, D. L., Pavlov, T. S. & Ilatovskaya, D. V., Jul 2023, In: American Journal of Physiology - Renal Physiology. 325, 1, p. F105-F120

Research output: Contribution to journal › Article › peer-review

​

Correction:T Cells Contribute to Pathological Responses in the Non-Targeted Rat Heart following Irradiation of the Kidneys(Toxics, (2022), 10, (797), 10.3390/toxics10120797)

Lenarczyk, M., Alsheikh, A. J., Cohen, E. P., Schaue, D., Kronenberg, A., Geurts, A., Klawikowski, S., Mattson, D. & Baker, J. E., Feb 2023, In: Toxics. 11, 2, 183.

Research output: Contribution to journal › Comment/debate › peer-review

​

Impact of bedding on Dahl salt-sensitive hypertension and renal damage

Dasinger, J. H., Walton, S. D., Burns, E. C., Cherian-Shaw, M., Abais-Battad, J. M. & Mattson, D. L., Dec 2022, In: American Journal of Physiology - Renal Physiology. 323, 6, p. F666-F672

Research output: Contribution to journal › Article › peer-review

​

Lymphatics and Blood Pressure

Mattson, D. L., Nov 1 2022, In: Hypertension. 79, 11, p. 2463-2464 2 p.

Research output: Contribution to journal › Editorial › peer-review

​

Gut-Immune-Kidney Axis: Influence of Dietary Protein in Salt-Sensitive Hypertension

Mattson, D. L., Dasinger, J. H. & Abais-Battad, J. M., Nov 1 2022, In: Hypertension. 79, 11, p. 2397-2408 12 p.

Research output: Contribution to journal › Review article › peer-review

​

Acute Increase of Renal Perfusion Pressure Causes Rapid Activation of mTORC1 (Mechanistic Target Of Rapamycin Complex 1) and Leukocyte Infiltration

Shimada, S., Yang, C., Kumar, V., Mattson, D. L. & Cowley, A. W., Jun 1 2022, In: Hypertension. 79, 6, p. 1180-1189 10 p.

Research output: Contribution to journal › Article › peer-review

​

Unique Associations of DNA Methylation Regions with 24-Hour Blood Pressure Phenotypes in Blacks

Roberts, M. L., Kotchen, T. A., Pan, X., Li, Y., Yang, C., Liu, P., Wang, T., Laud, P. W., Chelius, T. H., Munyura, Y., Mattson, D. L., Liu, Y., Cowley, A. W., Kidambi, S. & Liang, M., Apr 1 2022, In: Hypertension. 79, 4, p. 761-772 12 p.

Research output: Contribution to journal › Article › peer-review

​

T Cell Immunometabolism and Redox Signaling in Hypertension

Mattson, D. L. & Abais-Battad, J. M., Dec 2021, In: Current Hypertension Reports. 23, 12, 45.

Research output: Contribution to journal › Review article › peer-review

​

Make a difference—get involved

Mattson, D., May 2021, Physiologist, 64, 3, p. 36-37 2 p.

Research output: Contribution to specialist publication › Article

​

Dietary Sodium Restriction Results in Tissue-Specific Changes in DNA Methylation in Humans

Kidambi, S., Pan, X., Yang, C., Liu, P., Roberts, M. L., Li, Y., Wang, T., Laud, P. W., Liu, Y., Rubens, M., Thomas, R., Widlansky, M. E., Beyer, A. M., Liu, Y., Cowley, A. W., Kotchen, T. A., Munyura, Y., Moosreiner, A., Mattson, D. L. & Liang, M., Aug 1 2021, In: Hypertension. 78, 2, p. 434-446 13 p.

Research output: Contribution to journal › Article › peer-review

​

p66Shc-mediated hydrogen peroxide production impairs nephrogenesis causing reduction of number of glomeruli

Miller, B., Palygin, O., El-Meanawy, A., Mattson, D. L., Geurts, A. M., Staruschenko, A. & Sorokin, A., Aug 15 2021, In: Life sciences. 279, 119661.

Research output: Contribution to journal › Article › peer-review

​

Irradiation of the kidneys causes pathologic remodeling in the nontargeted heart: A role for the immune system

Lenarczyk, M., Laiakis, E. C., Mattson, D. L., Johnson, B. D., Kronenberg, A., North, P. E., Komorowski, R., Mäder, M. & Baker, J. E., Dec 2020, In: FASEB BioAdvances. 2, 12, p. 705-719 15 p.

Research output: Contribution to journal › Article › peer-review

​

Dietary protein source contributes to the risk of developing maternal syndrome in the Dahl salt-sensitive rat

Dasinger, J. H., Abais-Battad, J. M., Bukowy, J. D., Lund, H., Alsheikh, A. J., Fehrenbach, D. J., Zemaj, J. & Mattson, D. L., Jun 2021, In: Pregnancy Hypertension. 24, p. 126-134 9 p.

Research output: Contribution to journal › Article › peer-review

​

Team Science: American Heart Association's Hypertension Strategically Focused Research Network Experience

Santillan, M. K., Becker, R. C., Calhoun, D. A., Cowley, A. W., Flynn, J. T., Grobe, J. L., Kotchen, T. A., Lackland, D. T., Leslie, K. K., Liang, M., Mattson, D. L., Meyers, K. E., Mitsnefes, M. M., Muntner, P. M., Pierce, G. L., Pollock, J. S., Sigmund, C. D., Thomas, S. J., Urbina, E. M. & Kidambi, S., Jun 1 2021, In: Hypertension. 77, 6, p. 1857-1866 10 p.

Research output: Contribution to journal › Review article › peer-review

​

Dietary influences on the Dahl SS rat gut microbiota and its effects on salt-sensitive hypertension and renal damage

Abais-Battad, J. M., Saravia, F. L., Lund, H., Dasinger, J. H., Fehrenbach, D. J., Alsheikh, A. J., Zemaj, J., Kirby, J. R. & Mattson, D. L., Aug 2021, In: Acta Physiologica. 232, 4, e13662.

Research output: Contribution to journal › Article › peer-review

​

Contribution of Th17 cells to tissue injury in hypertension

Basile, D. P., Abais-Battad, J. M. & Mattson, D. L., Mar 2021, In: Current opinion in nephrology and hypertension. 30, 2, p. 151-158 8 p.

Research output: Contribution to journal › Review article › peer-review

​

Amplification of Salt-Sensitive Hypertension and Kidney Damage by Immune Mechanisms

Mattson, D. L., Dasinger, J. H. & Abais-Battad, J. M., Jan 1 2021, In: American journal of hypertension. 34, 1, p. 3-14 12 p.

Research output: Contribution to journal › Review article › peer-review

​

Sexual Dimorphic Role of CD14 (Cluster of Differentiation 14) in Salt-Sensitive Hypertension and Renal Injury

Fehrenbach, D. J., Abais-Battad, J. M., Dasinger, J. H., Lund, H., Keppel, T., Zemaj, J., Cherian-Shaw, M., Gundry, R. L., Geurts, A. M., Dwinell, M. R. & Mattson, D. L., Jan 1 2021, In: Hypertension. 77, 1, p. 228-240 13 p.

Research output: Contribution to journal › Article › peer-review

​

Renal Perfusion Pressure Determines Infiltration of Leukocytes in the Kidney of Rats with Angiotensin II-Induced Hypertension

Shimada, S., Abais-Battad, J. M., Alsheikh, A. J., Yang, C., Stumpf, M., Kurth, T., Mattson, D. L. & Cowley, A. W., Sep 1 2020, In: Hypertension. 76, 3, p. 849-858 10 p.

Research output: Contribution to journal › Article › peer-review

​

Influences of environmental factors during preeclampsia

Dasinger, J. H., Abais-Battad, J. M. & Mattson, D. L., Jul 2020, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 319, 1, p. R26-R32

Research output: Contribution to journal › Review article › peer-review

​

Inflammatory macrophages in the kidney contribute to salt-sensitive hypertension

Fehrenbach, D. J. & Mattson, D. L., Mar 2022, In: American Journal of Physiology - Renal Physiology. 318, 3, p. F544-F548

Research output: Contribution to journal › Review article › peer-review

​

Twenty-four-hour versus clinic blood pressure levels as predictors of long-term cardiovascular and renal disease outcomes among African Americans

Kidambi, S., Wang, T., Chelius, T., Nunuk, I., Agarwal, P., Laud, P., Mattson, D., Cowley, A. W., Liang, M. & Kotchen, T., Dec 1 2020, In: Scientific reports. 10, 1, 11685.

Research output: Contribution to journal › Article › peer-review

​

CCL2 mediates early renal leukocyte infiltration during salt-sensitive hypertension

Alsheikh, A. J., Dasinger, J. H., Abais-Battad, J. M., Fehrenbach, D. J., Yang, C., Cowley, A. W. & Mattson, D. L., Apr 2020, In: American Journal of Physiology - Renal Physiology. 318, 4, p. F982-F993

Research output: Contribution to journal › Article › peer-review

​

Animal Models of Hypertension: A Scientific Statement From the American Heart Association

Lerman, L. O., Kurtz, T. W., Touyz, R. M., Ellison, D. H., Chade, A. R., Crowley, S. D., Mattson, D. L., Mullins, J. J., Osborn, J., Eirin, A., Reckelhoff, J. F., Iadecola, C. & Coffman, T. M., Jun 1 2019, In: Hypertension (Dallas, Tex. : 1979). 73, 6, p. e87-e120

Research output: Contribution to journal › Review article › peer-review

View All Publications.

 

Read at Pub Med   

Cowley AW Jr, Roman RJ, Mattson DL, Franchini KG, O'Connor PM, Makino A, Taylor NE, Evans LC, Mori T, Dickhout JG, Jin C, Miyata N, Nakanishi K, Szentiványi M Jr, Park F, Skelton MM, Kurth T, Shimada S. Renal Medulla in Hypertension. Hypertension. 2024 Dec;81(12):2383-2394. doi: 10.1161/HYPERTENSIONAHA.124.21711. Epub 2024 Sep 30. PMID: 39344517

Dasinger JH, Abais-Battad JM, Walton SD, Burns-Ray EC, Cherian-Shaw M, Baldwin KE, Fehrenbach DJ, Mattson DL. Intact NOX2 in T Cells Mediates Pregnancy-Induced Renal Damage in Dahl SS Rats.  Hypertension. 2024 Nov;81(11):2357-2367. doi: 10.1161/HYPERTENSIONAHA.124.23303. Epub 2024 Sep 20.PMID: 39301728

Abais-Battad JM, Dasinger JH, Lund H, Burns-Ray EC, Walton SD, Baldwin KE, Fehrenbach DJ, Cherian-Shaw M, Mattson DL. Sex-Dependency of T Cell-Induced Salt-Sensitive Hypertension and Kidney Damage.  Hypertension. 2024 Jul;81(7):1511-1523. doi: 10.1161/HYPERTENSIONAHA.123.22608. Epub 2024 May 17.PMID: 38757269

 

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