I am interested in investigating the mechanisms of immune cell-mediated renal damage induced by blood pressure variability. We have established that hypertensive renal damage is associated with immune cell infiltration of the kidneys. My current study focuses on i) elucidating whether blood pressure variability without change in mean arterial pressure induces the same histological features associated with renal damage and ii) investigating immune cell gene expression levels in damaged renal tissue.
I am interested in studying pregnancy related diseases such as preeclampsia and gestational diabetes. My research involves studying the effects of acute kidney injury and obesity related hypertension and diabetes in pregnancy by using animal models to delineate how excess adipose tissue may cause endothelial damage and how renal damage may contribute to poor fetal outcomes.
I am interested in the function of the kidneys during angiotensin II dependent hypertension and specifically how sex differences influence the efficacy of treatment. My current project has shown that males and females respond differently to a mineralocorticoid receptor inhibitor, spironolactone, where females appear to have a better response to treatment. I would like to investigate the sex-specific mechanisms for these sex differences.
The main focus of my ongoing research is examining histamine's role in the nephron, as it pertains to maintaining and/or modulating podocyte and renal tubular cell function. Inflammation associated with salt-sensitive hypertension (SS-HTN) induces the release of pro-inflammatory signaling ligands, including histamine. Evidence from our lab demonstrates that the kidney not only responds to histamine via multiple histamine receptors, but also handles it using enzymes that synthesize and break histamine down. This project leverages ex vivo and in vitro calcium/nitric oxide imaging techniques, knockouts of histamine-handling enzymes in salt-sensitive rats, and modulation of histamine receptors pharmacologically in vivo.
My research interest revolves around better understanding salt-sensitive hypertension through examining how sodium contributes to immune dysregulation. Current work focuses on the involvement of the CD14/TLR4 complex pro-inflammatory response and how immune cell-derived ROS production drives exacerbation of hypertension and renal damage as a result of a high salt diet.
My research involves understanding the role of immune cell activation contributing to salt-induced blood pressure elevation. Ongoing project is investigating the role of IL-17 in salt-sensitive hypertension and renal damage in Dahl salt-sensitive rats.
My research interest revolves around how dietary changes impact cardiovascular health among males and females. Current work focuses on determining the impact of biological sex on blood pressure responses to a Western diet (high fat and high salt). We have confirmed that the Dahl rat is an excellent model to study the enhanced sensitivity of females to increases in dietary salt and fat, mirroring what is seen epidemiologically in women. We are focused on determining the mechanisms by which a high-fat diet predisposes females to the development of hypertension.
My research passion lies in investigating the intricate connections between vascular health and the vascular contributions to aging-, diabetes-, hypertension-related cognitive dysfunction, and Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD). Specifically, I focus on identifying novel therapeutic targets and elucidating underlying mechanisms to alleviate cerebral vascular and cognitive dysfunctions associated with AD/ADRD. By exploring these intersections, I aim to contribute to the development of effective strategies for combating the debilitating effects of these conditions on both vascular and cognitive health.
My research examines the interplay between factors impacting renal health and performance. Presently, I'm researching the repercussions of sleep deprivation on blood pressure regulation and renal integrity. Looking ahead, I plan to integrate dietary considerations in order to explore the consequences of a high-salt diet coupled with sleep deprivation in a model predisposed to salt-sensitive hypertension. Additionally, I'm actively examining the impact of nicotine-induced nitrosative stress on renal health, and I plan to examine the enduring effects of nicotine after smoking cessation.
I am interested in studying the connection between cardiometabolic disease and immune system activation and their roles as the driving force of hypertension leading to renal damage. It has been established that one of the symptoms of high fat diets is a gradual increase in blood pressure overtime leading to the eventual development of hypertension. My current project is studying the role of the NLRP3 inflammasome, which serves as a metabolic sensor for free fatty acids and when the inflammasome becomes active they release inflammatory cytokines, which serves as one of the drivers of hypertension.
Ongoing projects seek to determine the regulation and function of the hormone leptin in the development of cardiovascular and fetal consequences of preeclampsia. Elisabeth utilizes novel rodent models as well as patient-derived tissues to determine the mechanism whereby placental leptin increases in preeclampsia. Elisabeth also seeks to investigate whether anti-hypertensive therapies inhibit leptin-induced hypertension, vascular dysfunction and fetal growth restriction in rodent models of preeclampsia.
My research interest is in wound regeneration in the cornea. My current work focuses on investigating factors that lead to the impairment of corneal epithelial wound healing observed in diabetes mellitus.
I am interested in studying the sex-specific signaling mechanisms in chronic kidney disease (CKD). Our laboratory previously discovered that the upregulation of microRNA miR-146b has different roles in regulating CKD pathology in male and female rats. My project seeks to understand the interaction of pathological signaling pathways, miR-146b and gonadal hormones in the kidney.
I am interested in studying factors related to brain health and their contribution to the development of neurodegeneration and cognitive decline. My current research is focused on understanding the impact cardiovascular diseases have on the neurovascular unit. In particular, I am investigating how blood pressure variations affect neuroinflammation in the brain, a major contributor of cognitive decline. We have found that chronic blood pressure fluctuations increase pro-inflammatory markers, particularly those associated with microglial cells. Given the profound impact of cardiovascular disease on vascular dysfunction, my project will focus on glio-vascular signaling mechanisms. Our goal is to understand the cellular targets implicated in pressure-evoked microvascular dysfunction on increased glial (microglia and astrocytes) reactivity in the aging brain.
My research focuses on sex differences in renal mitochondrial function. Currently, I am investigating the effect of sex hormones on mitochondrial bioenergetics, such as oxygen consumption and reactive oxygen species at varying time points throughout life. Future research projects will be uncovering the mechanism that sex hormones act upon to create the differences between male and female renal mitochondria bioenergetics.
