Zsolt Bagi

Professor

Phone: (706) 721-8819
Fax: (706) 721-7299
Email: zbagi@augusta.edu
Office: CA-3133
Lab: CA-3132A

Education & Training

General Semmelweis University of Budap, Biomedical Sciences, PhD, 2004

Semmelweis University of Budap, Medicine, MD, 2000

Academic Appointments

2001-2010| Assistant Professor, New York Medical College
2010-2012 | Intermediate Research Fellow, British Heart Foundation Center of Research Excellence at University of Oxford
2011-2013 | Senior Research Fellow, Somerville College, Oxford University
2013 - 2019 | Associate Professor, Augusta University
2019 | Professor, Deparment of Physiology, Medical College of Georgia, Augusta University

Jump to: Research Interests Awards & Honors Related Links About Dr. Bagi's Research Lab

Dr. Bagi's Faculty Profile

LAB PERSONNEL

Liwei Lang, PhD
Assistant Research Scientist

Marta Bagine Balogh
Research Associate

Vadym Buncha
Graduate Student

Katherine Fopiano
Graduate Student

Research Interests

Coronary microvascular disease in patients with diabetes mellitus and diastolic heart failure.

Publication
Sex-specific molecular drivers of cardiac fibrosis in aging hearts Fopiano, K. A., Balogh, M. B., Patel, V. S., Ilatovskaya, D. V. & Bagi, Z., 2025, (Accepted/In press) In: GeroScience. Research output: Contribution to journal › Article › peer-review
Endothelial cell-selective adhesion molecule deficiency exhibits increased pulmonary vascular resistance due to impaired endothelial nitric oxide signaling Buncha, V., Lang, L., Fopiano, K. A., Ilatovskaya, D. V., Kapuku, G., Verin, A. D. & Bagi, Z., Feb 2025, In: American Journal of Physiology - Heart and Circulatory Physiology. 328, 2, p. H283-H293 Research output: Contribution to journal › Article › peer-review
PDE9A Inhibition Improves Coronary Microvascular Rarefaction and Left Ventricular Diastolic Dysfunction in the ZSF1 Rat Model of HFpEF Fopiano, K. A., Zhazykbayeva, S., El-Battrawy, I., Buncha, V., Pearson, W. M., Hardell, D. J., Lang, L., Hamdani, N. & Bagi, Z., Nov 2024, In: Microcirculation. 31, 8, e12888. Research output: Contribution to journal › Article › peer-review
Altered copper transport in oxidative stress-dependent brain endothelial barrier dysfunction associated with Alzheimer's disease Hossain, M. S., Das, A., Rafiq, A. M., Deák, F., Bagi, Z., Outlaw, R., Sudhahar, V., Yamamoto, M., Kaplan, J. H., Ushio-Fukai, M. & Fukai, T., Dec 2024, In: Vascular Pharmacology. 157, 107433. Research output: Contribution to journal › Article › peer-review
Phosphodiesterase 9A inhibition improves aging-related increase in pulmonary vascular resistance in mice Buncha, V., Fopiano, K. A., Lang, L., Ilatovskaya, D. V., Verin, A. & Bagi, Z., Oct 2024, In: GeroScience. 46, 5, p. 5191-5202 12 p. Research output: Contribution to journal › Article › peer-review
AGPAT3 deficiency impairs adipocyte differentiation and leads to a lean phenotype in mice Zhou, H., Fick, K., Patel, V., Hilton, L. R., Kim, H. W., Bagi, Z., Weintraub, N. L. & Chen, W., Jul 2024, In: American Journal of Physiology - Endocrinology and Metabolism. 327, 1, p. E69-E80 Research output: Contribution to journal › Article › peer-review
Zinc-Dependent Histone Deacetylases in Lung Endothelial Pathobiology Patil, R. S., Maloney, M. E., Lucas, R., Fulton, D. J. R., Patel, V., Bagi, Z., Kovacs-Kasa, A., Kovacs, L., Su, Y. & Verin, A. D., Feb 2024, In: Biomolecules. 14, 2, 140. Research output: Contribution to journal › Review article › peer-review
The role of ADAM17 in cerebrovascular and cognitive function in the APP/PS1 mouse model of Alzheimer’s disease Tian, Y., Fopiano, K. A., Buncha, V., Lang, L., Suggs, H. A., Wang, R., Rudic, R. D., Filosa, J. A. & Bagi, Z., 2023, In: Frontiers in Molecular Neuroscience. 16, 1125932. Research output: Contribution to journal › Article › peer-review
Microvascular contributions to white matter injury in Alzheimer’s disease Bagi, Z., Sherman, L. S. & Back, S. A., 2023, In: Aging. 15, 16, p. 7860-7862 3 p. Research output: Contribution to journal › Editorial › peer-review
Mice with endothelial cell-selective adhesion molecule deficiency develop coronary microvascular rarefaction and left ventricle diastolic dysfunction Buncha, V., Fopiano, K. A., Lang, L., Williams, C., Horuzsko, A., Filosa, J. A., Kapuku, G. & Bagi, Z., Mar 2023, In: Physiological reports. 11, 6, e15643. Research output: Contribution to journal › Article › peer-review
Multispectral LEDs Eliminate Lipofuscin-Associated Autofluorescence for Immunohistochemistry and CD44 Variant Detection by in Situ Hybridization in Aging Human, non-Human Primate, and Murine Brain Adeniyi, P. A., Fopiano, K. A., Banine, F., Garcia, M., Gong, X., Keene, C. D., Sherman, L. S., Bagi, Z. & Back, S. A., 2022, In: ASN Neuro. 14 Research output: Contribution to journal › Article › peer-review
Deficiency of Myeloid Pfkfb3 Protects Mice From Lung Edema and Cardiac Dysfunction in LPS-Induced Endotoxemia Xu, J., Wang, L., Yang, Q., Ma, Q., Zhou, Y., Cai, Y., Mao, X., Da, Q., Lu, T., Su, Y., Bagi, Z., Lucas, R., Liu, Z., Hong, M., Ouyang, K. & Jiao, K., 2021, In: Frontiers in Cardiovascular Medicine. 8, p. 745810 745810. Research output: Contribution to journal › Article › peer-review
Association of cerebral microvascular dysfunction and white matter injury in Alzheimer’s disease Bagi, Z., Kroenke, C. D., Fopiano, K. A., Tian, Y., Filosa, J. A., Sherman, L. S., Larson, E. B., Keene, C. D., Degener O’Brien, K., Adeniyi, P. A. & Back, S. A., Aug 2022, In: GeroScience. 44, 4, p. 1-14 14 p. Research output: Contribution to journal › Article › peer-review
Coronary Microvascular Dysfunction and Heart Failure with Preserved Ejection Fraction-implications for Chronic Inflammatory Mechanisms Fopiano, K. A., Jalnapurkar, S., Davila, A. C., Arora, V. & Bagi, Z., Mar 2022, In: Current Cardiology Reviews. 18, 2, p. 6-14 9 p., e310821195986. Research output: Contribution to journal › Article › peer-review
Role of Caveolae in the Development of Microvascular Dysfunction and Hyperglycemia in Type 2 Diabetes Tian, Y., Fopiano, K. A., Patel, V. S., Feher, A. & Bagi, Z., Feb 18 2022, In: Frontiers in Physiology. 13, 825018. Research output: Contribution to journal › Article › peer-review
GDP in Dialysis Associates with Peritoneal Vascular Remodeling in Kidney Disease Han, Q., Orr, Z. J., DeSouza, G. K., Bagi, Z. & Rudic, R. D., Aug 20 2021, In: Circulation research. 129, 5, p. 527-529 3 p. Research output: Contribution to journal › Review article › peer-review
Aging-induced impaired endothelial wall shear stress mechanosensing causes arterial remodeling via JAM-A/F11R shedding by ADAM17 Tian, Y., Fopiano, K. A., Buncha, V., Lang, L., Rudic, R. D., Filosa, J. A., Dou, H. & Bagi, Z., Feb 2022, In: GeroScience. 44, 1, p. 349-369 21 p. Research output: Contribution to journal › Article › peer-review
Review: Circadian clocks and rhythms in the vascular tree Han, Q., Bagi, Z. & Daniel Rudic, R., Aug 2021, In: Current Opinion in Pharmacology. 59, p. 52-60 9 p. Research output: Contribution to journal › Review article › peer-review
Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidation Kolijn, D., Pabel, S., Tian, Y., Lódi, M., Herwig, M., Carrizzo, A., Zhazykbayeva, S., Kovács, Á., Fülöp, G., Falcão-Pires, I., Reusch, P. H., Linthout, S. V., Papp, Z., Van Heerebeek, L., Vecchione, C., Maier, L. S., Ciccarelli, M., Tschöpe, C., Mügge, A. & Bagi, Z. & 2 others, Sossalla, S. & Hamdani, N., Feb 1 2021, In: Cardiovascular Research. 117, 2, p. 495-507 13 p. Research output: Contribution to journal › Article › peer-review
A Novel Subset of CD95⁺ Pro-Inflammatory Macrophages Overcome miR155 Deficiency and May Serve as a Switch From Metabolically Healthy Obesity to Metabolically Unhealthy Obesity Johnson, C., Drummer IV, C., Shan, H., Shao, Y., Sun, Y., Lu, Y., Saaoud, F., Xu, K., Nanayakkara, G., Fang, P., Bagi, Z., Jiang, X., Choi, E. T., Wang, H. & Yang, X., Jan 7 2021, In: Frontiers in immunology. 11, 619951. Research output: Contribution to journal › Article › peer-review
Effects of race, cardiac mass, and cardiac load on myocardial function trajectories from childhood to young adulthood: The augusta heart study Kapuku, G., Howie, M., Ghosh, S., Doshi, V., Bykhovsky, M., Ange, B., Halbert, J. D., Robinson, V., Bagi, Z., Harshfield, G. & George, V., 2021, In: Journal of the American Heart Association. 10, 3, p. 1-8 8 p., e015612. Research output: Contribution to journal › Article › peer-review
Rapid decline of resting heart rate trajectories from childhood to young adulthood is paradoxically associated with increased cardiac mass Hao, G., Halbert, J., Su, S., Bagi, Z., Robinson, V., Thayer, J., Harshfield, G. & Kapuku, G., 2021, In: Acta Cardiologica. 76, 10, p. 1117-1123 7 p. Research output: Contribution to journal › Article › peer-review
Prkaa1 Metabolically Regulates Monocyte/Macrophage Recruitment and Viability in Diet-Induced Murine Metabolic Disorders Yang, Q., Ma, Q., Xu, J., Liu, Z., Zou, J., Shen, J., Zhou, Y., Da, Q., Mao, X., Lu, S., Fulton, D. J., Weintraub, N. L., Bagi, Z., Hong, M. & Huo, Y., 2020, In: Frontiers in Cell and Developmental Biology. 8, p. 611354 611354. Research output: Contribution to journal › Article › peer-review
Vasculo-Neuronal Coupling and Neurovascular Coupling at the Neurovascular Unit: Impact of Hypertension Presa, J. L., Saravia, F., Bagi, Z. & Filosa, J. A., Sep 25 2020, In: Frontiers in Physiology. 11, 584135. Research output: Contribution to journal › Review article › peer-review
Adenosine kinase inhibition enhances microvascular dilator function and improves left ventricle diastolic dysfunction Davila, A., Tian, Y., Czikora, I., S. Weissman, A., Weinand, N., Dong, G., Xu, J., Li, J., Su, H., Kapuku, G., Huo, Y. & Bagi, Z., Aug 1 2020, In: Microcirculation. 27, 6, e12624. Research output: Contribution to journal › Article › peer-review
Endothelial adenosine kinase deficiency ameliorates diet-induced insulin resistance Xu, J., Yang, Q., Zhang, X., Liu, Z., Cao, Y., Wang, L., Zhou, Y., Zeng, X., Ma, Q., Xu, Y., Wang, Y., Huang, L., Han, Z., Wang, T., Stepp, D., Bagi, Z., Wu, C., Hong, M. & Huo, Y., Aug 2019, In: Journal of Endocrinology. 242, 2, p. 159-172 14 p. Research output: Contribution to journal › Article › peer-review
Adenosine kinase inhibition augments conducted vasodilation and prevents left ventricle diastolic dysfunction in heart failure with preserved ejection fraction Davila, A., Tian, Y., Czikora, I., Li, J., Su, H., Huo, Y., Patel, V., Robinson, V., Kapuku, G., Weintraub, N. & Bagi, Z., Aug 1 2019, In: Circulation: Heart Failure. 12, 8, e005762. Research output: Contribution to journal › Article › peer-review
Extracellular vesicle integrins act as a nexus for platelet adhesion in cerebral microvessels Bagi, Z., Couch, Y., Broskova, Z., Perez-Balderas, F., Yeo, T., Davis, S., Fischer, R., Sibson, N. R., Davis, B. G. & Anthony, D. C., Dec 1 2019, In: Scientific reports. 9, 1, 15847. Research output: Contribution to journal › Article › peer-review
Akt2 (protein kinase B beta) stabilizes ATP7A, a copper transporter for extracellular superoxide dismutase, in vascular smooth muscle: Novel mechanism to limit endothelial dysfunction in type 2 diabetes mellitus Sudhahar, V., Okur, M. N., Bagi, Z., O'Bryan, J. P., Hay, N., Makino, A., Patel, V. S., Phillips, S. A., Stepp, D., Ushio-Fukai, M. & Fukai, T., 2018, In: Arteriosclerosis, thrombosis, and vascular biology. 38, 3, p. 529-541 13 p. Research output: Contribution to journal › Article › peer-review
Too much TRAFfic at the crossroads of diabetes and endothelial dysfunction Bagi, Z., Jan 2018, In: American Journal of Physiology - Heart and Circulatory Physiology. 314, 1, p. H65-H67 Research output: Contribution to journal › Editorial › peer-review

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Awards & Honors

Bristol-Myers Squibb Young Investigator Award of the American Physiological Society

2008

ATVB Merit Award of the American Heart Association

2007

Van Leeuwenhoek Distinctive Travel Award of the European Society for Microcirculation

2004

Zweifach Student Award of the American Microcirculatory Society

2004

Caroline tum Suden/Frances A. Hellenbrandt Award, American Physiological Society

2003