Alison Kriegel, PhD, FAHA
Professor of Physiology
706-721-0698
akriegel@augusta.edu
Office: CA-3096 | Lab: CA:3097
706-721-7299
Lauren Yunker, Graduate Student
Education & TrainingACADEMIC APPT.Research InterestsAwards & AccomplishmentsPublications
University of Wisconsin-Milwaukee, Milwaukee, WI, BS in Biological Sciences, 2001
Marquette University, Milwaukee, WI, Graduate studies in exercise/skeletal muscle physiology 2002-2004
Medical College of Wisconsin, Milwaukee, WI, PhD in Biomedical Sciences, Physiology Program, 2008
Medical College of Wisconsin, Milwaukee, WI, postdoctoral fellowship in molecular regulation of renal pathology
Professor, Department of Physiology, Medical College of Georgia at Augusta University
Secondary Appointment, Department of Pediatrics, Nephrology Research Leader, Division of Nephrology, Children’s Research Institute, Medical College of Wisconsin
Associate Professor, Department of Physiology, MCW
Secondary Appointment, School of Pharmacy, Medical College of Wisconsin
Assistant Professor, Department of Physiology, MCW
Instructor, Anatomy and Physiology, Natural Sciences Department, Milwaukee Area Technical College, Milwaukee, WI
Adjunct Faculty, Biology Program, Carroll University, Waukesha, WI
My research interests are broadly focused on understanding how alterations in microRNAs (miRNAs), protein coding genes, and metabolites influence cardiovascular disease, cardiorenal syndrome, and renal disease. We utilize discovery-based approaches to studying these complex problems by blending next-generation technologies with molecular biology techniques, systems physiology, classical physiological studies, and translational research.
Our current work is focused in three main areas:
1) determining mechanisms regulating declining renal function in hypertension, diabetes and CKD,
2) determining mechanisms regulating cardiovascular dysfunction in cardiorenal syndrome and during cancer treatment, and
3) understanding fundamental sex differences in renal and cardiovascular physiology and pathophysiology.
2023 Renal Section Young Investigator Award Winner, American Physiological Society
2023, 2018-2021 Outstanding Graduate School Educator, Graduate School of Biomedical Sciences, Medical College of Wisconsin
2021-2023 Outstanding Medical Student Teacher, Medical School, Medical College of Wisconsin
2022 Postdoc Mentor of the Year, Medical College of Wisconsin
2021- 2022 Research and Community Scholars Program, Cancer Center, Medical College of Wisconsin
2020 – 2021 Women’s Leadership Program, Center for the Advancement of Women in Science and Medicine (AWSM), Medical College of Wisconsin
2020 Mentor of the Year Award, Graduate School, Medical College of Wisconsin
2018 Elected a Fellow of the American Heart Association (FAHA); Council on the Kidney in Cardiovascular Disease (KCVD)
2013 – 2015 Clinical Research Scholar’s Program, Clinical and Translational Sciences Institute, Medical College of Wisconsin
Nasci VL, Liu P, Marks AM, Williams AC, Kriegel AJ. Transcriptomic analysis identifies novel candidates in cardiorenal pathology mediated by chronic peritoneal dialysis. Sci Rep. 2023 Jun 21;13(1):10051. doi: 10.1038/s41598-023-36647-7. PMID: 37344499; PMCID: PMC10284882.
Williams AC, Singh V, Liu P, Kriegel AJ. Liquid Biopsies Poorly miRror Renal Ischemia-Reperfusion Injury. Noncoding RNA. 2023 Apr 1;9(2):24. doi: 10.3390/ncrna9020024. PMID: 37104006; PMCID: PMC10141369.
Adam RJ, Paterson MR, Wardecke L, Hoffmann BR, Kriegel AJ. Functionally Essential Tubular Proteins Are Lost to Urine-Excreted, Large Extracellular Vesicles during Chronic Renal Insufficiency. Kidney360. 2020 Oct;1(10):1105-1115. doi: 10.34067/kid.0001212020. Epub 2020 Oct 29. PMID: 34263177; PMCID: PMC8276873.
Nasci VL, Chuppa S, Griswold L, Goodreau KA, Dash RK, Kriegel AJ. miR-21-5p regulates mitochondrial respiration and lipid content in H9C2 cells. Am J Physiol Heart Circ Physiol. 2019 Mar 1;316(3):H710-H721. doi: 10.1152/ajpheart.00538.2017. Epub 2019 Jan 18. PMID: 30657727; PMCID: PMC6459316.
Kriegel AJ, Terhune SS, Greene AS, Noon KR, Pereckas MS, Liang M. Isomer-specific effect of microRNA miR-29b on nuclear morphology. J Biol Chem. 2018 Sep 7;293(36):14080-14088. doi: 10.1074/jbc.RA117.001705. Epub 2018 Jul 13. PMID: 30006350; PMCID: PMC6130969.
Chuppa S, Liang M, Liu P, Liu Y, Casati MC, Cowley AW, Patullo L, Kriegel AJ. MicroRNA-21 regulates peroxisome proliferator-activated receptor alpha, a molecular mechanism of cardiac pathology in Cardiorenal Syndrome Type 4. Kidney Int. 2018 Feb;93(2):375-389. doi: 10.1016/j.kint.2017.05.014. Epub 2017 Jul 29. PMID: 28760335; PMCID: PMC5787401.
Kriegel AJ, Gartz M, Afzal MZ, de Lange WJ, Ralphe JC, Strande JL. Molecular Approaches in HFpEF: MicroRNAs and iPSC-Derived Cardiomyocytes. J Cardiovasc Transl Res. 2017 Jun;10(3):295-304. doi: 10.1007/s12265-016-9723-z. Epub 2016 Dec 28. PMID: 28032312; PMCID: PMC5937699.
Kriegel AJ, Baker MA, Liu Y, Liu P, Cowley AW Jr, Liang M. Endogenous microRNAs in human microvascular endothelial cells regulate mRNAs encoded by hypertension-related genes. Hypertension. 2015 Oct;66(4):793-9. doi: 10.1161/HYPERTENSIONAHA.115.05645. Epub 2015 Aug 17. PMID: 26283043; PMCID: PMC4567475.
