Guangyu Wu, PhD
Research Interest, Education and Publications
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Research & Education Building, CB 3528
Office phone icon: 706-721-0999
Lab phone icon: 706-721-9860
Members of the Lab |
RESEARCH INTEREST
Intracellular trafficking, signal regulation and patho-physiological functions of G protein-coupled receptors and G proteins.
EDUCATION AND POST-DOCTORAL TRAINING
1995 -1998 Post-Doctoral Fellowship Medical University of South Carolina
1992 Ph.D in Physiology Peking Union Medical College
and Chinese Academy of Medical Sciences, China
1988 M.S. in Biochemistry Xuzhou Medical College,
China
1983 B.S. in Biochemistry Beijing Normal University,
China
ACADEMIC APPOINTMENTS
2011 - Present Professor (with Tenure), Department of Pharmacology and Toxicology, MCG, Augusta University, Augusta, GA.
2001 - 2011 Assistant/Associate Professor, Department of Pharmacology and Experimental Therapeutics, Louisiana State
University Health Sciences Center New Orleans, LA.
1999 - 2001 Assistant Professor, Department of Internal Medicine, University of Cincinnati, OH
EDITORIAL BOARDS
Frontiers in Bioscience – Landmark
Frontiers in Neuroscience
iScience
PLoS ONE
CONTRIBUTIONS TO SCIENCE
Khater M, Bryant CN and Wu G. Gbgtranslocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein-coupled receptor signaling to MAPK. J Biol Chem 296:100805 (2021)
Khater M, Wei Z, Xu X, Huang W, Lokeshwar BL, Lambert NA and Wu G. G protein bg translocation to the Golgi apparatus activates MAPK via PI3Kg. J Biol Chem 296:100325 (2021)
Wei Z, Xu X, Fang Y, Khater M, Naughton SX, Hu G, Terry AV Jr. and Wu G. Rab43 GTPase directs post-synaptic trafficking and neuron-specific sorting of G protein-coupled receptors. J Biol Chem 296:100517 (2021)
Fang Y, Jiang Q, Li S, Zhu H, Xu R, Song N, Ding X, Liu J, Chen M, Song M, Ding J, Lu M, Wu G and Hu G. Opposing functions of β-arrestin1 and 2 in Parkinson’s disease via microglia inflammation and Nprl3. Cell Death Differ 28(6):1822-1836 (2021)
Zhang M, Xu X, Li C, Huang W, Xu N, and Wu G. A naturally occurring splice variant of GGA1 inhibits the anterograde post-Golgi traffic of a2B-adrenergic receptor. Sci Rep 9:10378 (2019)
Wei Z, Zhang M, Li C, Huang W, Fan Y, Guo J, Khater M, Fukuda M, Dong Z, Hu G and Wu G. Specific TBC domain-containing proteins control the ER-Golgi-plasma membrane trafficking of GPCRs. Cell Rep 28(2):554-566 (2019)
Li ZW, Sun B, Gong T, Guo S, Zhang J, Wang J, Sugawara A, Jiang M, Yan J, Gurary A, Zheng X, Gao B, Xiao SY, Chen W, Ma C, Farrar C, Zhu C, Chan OTM, Xin C, Winnicki A, Winnicki J, Tang M, Park R, Winnicki M, Diener K, Wang Z, Liu Q, Chu CH, Arter ZL, Yue P, Alpert L, Hui GS, Fei P, Turkson J, Yang W, Wu G, Tao A, Ramos JW, Moisyadi S, Holcombe RF, Jia W, Birnbaumer L, Zhou X and Chu WM. GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and downregulating expression of GNAI. Gastroenterology 156(8):2297-2312 (2019)
Li C, Wei Z, Fan Y, Huang W, Su Y, Li H, Dong Z, Fukuda M, Khater M and Wu G. The GTPase Rab43 controls the anterograde ER-Golgi trafficking and sorting of GPCRs. Cell Rep 21(4):1089-1101 (2017)
Zhang M, Huang W, Gao J, Terry AV Jr and Wu G. Regulation of α2B-adrenergic receptor cell surface transport by GGA1 and GGA2. Sci Rep 6:37921 (2016)
Zhang M, Davis JE, Li C, Gao J, Huang W, Lambert NA, Terry AV Jr. and Wu G. GGA3 interacts with a G protein-coupled receptor and modulates its cell surface export. Mol Cell Biol 36(7):1152-1163 (2016)