Nevin A. Lambert, PhD

Research Interest, Education & Publications

photo of Nevin A. Lambert, PhD

Nevin A. Lambert, PhD

  • Regent's Professor
  • Vice Chair for Research
  • Pharmacology & Toxicology

706-721-6336
Research & Education Building, CB 3522

Office phone icon: 706-721-6336
Lab phone icon: 706-721-6337

 

Members of the Lab

Sumin Lu, PhD

  • Postdoctoral Fellow

Kanishka Jayasekara Hettiarach, PhD

  • Postdoctoral Fellow

RESEARCH INTEREST

The Lambert Lab studies the molecular pharmacology of G protein-coupled receptors (GPCRs) and their downstream signaling partners. We use cell-based and biophysical approaches to ask questions about how GPCRs, G proteins and effectors are arranged and interact in cells.

 

EDUCATION AND POST-DOCTORAL TRAINING

1990       BS, Youngstown State University
1991       PhD, Kent State University
1996       Postdoctoral, Duke University

ACADEMIC/ADMINISTRATIVE APPOINTMENTS

Regents’ Professor

Vice-Chair, Department of Pharmacology and Toxicology

EDITORIAL BOARDS

Journal of Biological Chemistry
Molecular Pharmacology
Frontiers in Endocrinology

GRANT REVIEW PANELS

Molecular Neuropharmacology and Signaling (MNPS), NIH (chair)

HONORS

My dog seems to like me

CONTRIBUTIONS TO SCIENCE

Jang, W., Lu, S., Xu, X., Wu, G. and Lambert, N.A. The role of G protein conformation in receptor-G protein selectivity. Nature Chemical Biology, 19:687–694, 2023.

Asher, W.B., Terry, D.S., Gregorio, G.G.A., Kahsai, A.W., Borgia, A., Xie, B., Modak, A., Zhu, Y., Jang, W., Govindaraju, A., Huang, L., Inoue, A., Lambert, N.A., Gurevich, V.V., Shi, L., Lefkowitz, R.J., Blanchard, S.C. and Javitch, J.A. GPCR-mediated b-arrestin Activation Deconvoluted with Single-molecule Precision. Cell, 185(10):1661-1675, 2022.

Wright, S.C., Lukasheva, V., Le Gouill, C., Kobayashi, H., Breton, B., Mailhot-Larouche, S., Blondel-Tepaz, É, Vieira, N.A., Costa-Neto, C., Héroux, M., Lambert, N.A., Parreiras-e-Silva, L.T. and Bouvier, M. BRET-based effector membrane translocation assay monitors GPCR-promoted and endocytosis-mediated Gq activation at early endosomes. Proc. Natl. Acad. Sci. USA, 118(20):e2025846118, 2021.

Lu, S., Jang, W., Inoue, A. and Lambert N.A. Constitutive G protein coupling profiles of understudied orphan GPCRs. PLOS ONE, 16(4):e0247743, 2021.

Jang, W., Adams, C.E., Liu, H., Zhang, C., Levy, F.O., Andressen, K.W. and Lambert, N.A. An inactive receptor-G protein complex maintains the dynamic range of agonist-induced signaling. Proc. Natl. Acad. Sci. USA, 117 (48):30755-30762, 2020.

Okashah, N., Wright, S.C., Kawakami, K., Mathiasen, S., Zhou, J., Lu, S., Javitch, J.A., Inoue, A., Bouvier, M. and Lambert, N.A. Agonist-induced formation of unproductive receptor-G12 complexes. Proc. Natl. Acad. Sci. USA, 117(35):21723-21730, 2020.

Bondar, A., Jang, W., Sviridova, E. and Lambert, N.A. Components of the Gs signaling cascade exhibit distinct changes in mobility and membrane domain localization upon 2-adrenergic receptor activation. Traffic, 21(4):324-332, 2020.

Okashah, N. Wan, Q., Ghosh, S., Sandhu, M., Inoue, A., Vaidehi, N. and Lambert, N.A. Variable G protein determinants of GPCR coupling selectivity. Proc. Natl. Acad. Sci. USA, 116 (24):12054-12059, 2019.

Wan, Q., Okashah, N., Inoue, A., Nehmé, R., Carpenter, B., Tate, C.G. and Lambert, N.A. Mini G protein probes for active G protein-coupled receptors (GPCRs) in live cells. Journal of Biological Chemistry, 293(19) 7466 –7473, 2018. (selected as “Editor’s Pick”; most read JBC paper of 2018)

 

 Complete list of publications