Rafal Pacholczyk
Assistant Professor
Academic Appointment(s)
Medical College of Georgia
Department of Biochemistry and Molecular Biology
Medical College of Georgia
Department of Medicine
The Graduate School
Medical College of Georgia
Department of Medicine: Endocrinology
- (706) 721-3528
- (706) 721-3482
- CN 4132
Education
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Ph.D., Immunology
Polish Academy of Science, 2002
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MS, Biotechnology
University of Technology, 1995
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BS, Biotechnology
University of Technology, 1994
Courses Taught Most Recent Academic Year
Scholarship
Selected Recent Publications
- IRAK1-regulated IFN-gamma signaling induces MDSC to facilitate immune evasion in FGFR1-driven hematological malignancies, 2021
Journal Article, Academic Journal
- A Tryptophan-Deficient Diet Induces Gut Microbiota Dysbiosis and Increases Systemic Inflammation in Aged Mice, 2021
Journal Article, Academic Journal
- FIRST-IN-CHILDREN PHASE 1B STUDY USING THE IDO PATHWAY INHIBITOR INDOXIMOD IN COMBINATION WITH RADIATION AND CHEMOTHERAPY FOR CHILDREN WITH NEWLY DIAGNOSED DIPG (NCT02502708, NLG2105), 2021
Conference Proceeding
- Phase II trial of the IDO pathway inhibitor indoximod plus pembrolizumab for the treatment of patients with advanced melanoma, 2021
Journal Article, Academic Journal
- Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity, 2021
Journal Article, Academic Journal
Research Interests
During over 25 years of my training and research career, I gained broad expertise in basic and molecular immunology, specifically in the role of TCR/peptide/MHC interactions in different aspects of autoimmune diseases and tolerance using in vivo and in vitro assays in animal models. My current research interest focuses on braking the pathologic state of "tolerance" created in the tumor microenvironment, which is the goal of cancer immunotherapy. I'm designing and supervising immune-monitoring assays used in several Immunotherapy clinical trials.
