Huabo Su
Professor
Academic Appointment(s)
Medical College of Georgia
Department of Pharmacology and Toxicology
The Graduate School
Medical College of Georgia
Department of Vascular Biology Center
Administration
Department of The Graduate School
Education
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Ph.D., Biochemistry and Molecular Biology
Fudan University, 2004
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MD, Molecular Biology
Guangxi University, 2001
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BS, Bio, General
Guangxi Normal University, 1997
Awards & Honors
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APS-CV section fellow
American Physiology Society Cardiovascular Section, 2022
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RO1, NHLB1, PI, 2019-2024
2019
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AHA CDA (to Z.J.), Sponsor, 2019-2022
2019
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AHA TPA, PI, 2019-2022
2019
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AHA Postdoc Fellowship (to Z.J.), Sponsor, 2017-2019
2017
Courses Taught Most Recent Academic Year
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VBIO 9300
Research in Vascular Bio
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BIOM 8130
Scientific Grant Writing
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VBIO 9010
Seminar in Vascular Bio
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VBIO 9210
Investigation of a Prob
Scholarship
Selected Recent Publications
- Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis, 2022
Journal Article, Academic Journal
- BSCL2/Seipin deficiency in hearts causes cardiac energy deficit and dysfunction via inducing excessive lipid catabolism., 2022
Journal Article, Academic Journal
- Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis., 2022
Journal Article, Academic Journal
- Cullin 2-RBX1 E3 ligase and USP2 regulate antithrombin ubiquitination and stability, 2021
Journal Article, Academic Journal
- Editorial: Post-translational Modifications and Compartmentalized Protein Quality Control in Cardiac Muscle and Disease, 2021
Journal Article, Academic Journal
Research Interests
My research focuses on understanding the biological function of ubiquitin-like protein modifiers including NEDD8 and Ufm1 in cardiomyocytes, with an ultimate goal to elucidate the molecular mechanisms of heart failure and to search for novel therapeutic measures. We are particularly interested in addressing three major questions: are neddylation and ufmylation essential for cardiac function under physiological and pathological conditions? How does each modification control different cellular processes in cardiomyocyte? What proteins are targeted by NEDD8 or Ufm1 in cardiomyocytes, and how does such modification regulate the molecular function of the target? We employ in vitro molecular and cellular biology approaches, proteomics approach and the state-of-the-art in vivo mouse physiology analyses to address these questions.
Department Service
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2018 VBC Faculty Search Committee
2019 - Present
Role: Committee Member
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Research Integrity Committee
2018 - Present
Role: Committee Member
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Vascular Biology Center Journal Club
2015 - Present
Role: Other
College Service
Professional Service
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AHA, Transformative Project Award, Cardiac Biology BSc Committee
2022 - Present
Role: Reviewer, Ad Hoc Reviewer
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Moderator, ACRE-CAAC Joint Seminar Series 2022, Feb 23, 2022, Virtual
2022 - Present
Role: Conference-Related
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Research Grants Council, Hong Kong, China
2022 - Present
Role: Reviewer, Ad Hoc Reviewer
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NIH, NIH Directors Early Independence Awards ZRG1 PSE-H 70 (DP5 mechanism)
2021 - Present
Role: Reviewer, Ad Hoc Reviewer
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NIH, Special Emphasis panel ZRG1 CVRS-Q (02)
2021 - Present
Role: Reviewer, Ad Hoc Reviewer
