Dept. of Biological Sciences – College of Science & Mathematics
Dept. of Neuroscience & Regenerative Medicine – MCG
Mailing Address:
Dept. of Neuroscience & Regenerative Medicine
1201 Goss Lane - GE2017
Augusta University
Augusta, GA 30912
icon Phone: (706) 723-4391
icon E-mail: egoldstein@augusta.edu
Brain damage induced by premature birth is the leading cause of neurodevelopmental disabilities. Research in my lab investigates the pathogenesis and repair of diffuse white matter injury – the most common neuropathological outcome of premature birth. Clinical studies demonstrate that environmental factors can benefit recovery from white matter injury, however specific mechanisms driving progression and recovery are not well understood. Our previous work found that recovery in an enriched environment ameliorates developmental brain injury and promotes functional recovery. The current focus in the lab is to identify how environmental stimuli direct cell and molecular changes in the brain. Using a mouse model of diffuse white matter injury or postmortem preterm infant brain samples, we are investigating the role of histone modifications in white matter injury. Our studies will inform the quest to develop improved therapeutic options for babies born preterm.
*Authors contributed equally. # Co-corresponding authors.
