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Dean of the Medical College of Georgia

Dr. David Hess

David C. Hess, MD

Dean, Medical College of Georgia
EVP, Medical Affairs and Integration, Augusta University
MCG Presidential Distinguished Chair
Professor, Neurology


Educational Background

  • MD, Medicine – University of Maryland, Baltimore
  • BA, Humanities – Johns Hopkins University

Biography:

David C. Hess MD, a stroke specialist, federally funded investigator, honored educator and biotech entrepreneur, is the 27th Dean of the Medical College of Georgia and Executive Vice President for Medical Affairs and Integration at Augusta University.

Dr. Hess also continues to serve as Presidential Distinguished Chair and as a Professor in the MCG Department of Neurology. He is a graduate of the Johns Hopkins University and the University of Maryland School of Medicine. He is triple board certified in Internal Medicine, Neurology, and Vascular Neurology. He completed his Neurology residency and Vascular Neurology/Stroke fellowship at MCG and AU Health System.

As MCG Dean, Dr. Hess has helped oversee the most significant curriculum change in MCG’s history to better address the need for more primary care physicians in Georgia and beyond and to enable all students to better tailor their medical education to optimally meet their future practice plans. He has expanded the scope and depth of scientific discovery regarding the state and nation’s major health issues, including establishing the Center for Healthy Aging and the Immunology Center of Georgia.

A prolific physician-scientist whose focus is improving stroke treatment and recovery, Dr. Hess has over 250 peer-reviewed publications and has been involved in basic, pre-clinical and clinical stroke research. He currently is the Principal Investigator on two National Institutes of Health grants. He served as the clinical principal investigator for the MASTERS clinical trial, a study of bone-marrow derived stem cells known as “Multistem” in acute stroke, the largest stem cell trial for stroke to date in the United States.

Dr. Hess helped develop the REACH telestroke network in rural Georgia that now numbers more than 20 hospitals. REACH enables timely stroke diagnosis and treatment by using the internet to eliminate distance between patients and stroke specialists. He also co-founded and chaired the Board of Directors of REACH Health Inc., a telestroke company that spun out of MCG and now also provides similar services for a variety of acute medical problems to patients, physicians and hospitals worldwide. REACH Health Inc., based in Atlanta, was sold to InTouch and later Teladocs in 2019.

Dr. Hess has a major interest in the area of remote ischemic limb conditioning (RIC) as a treatment for acute ischemic stroke and vascular cognitive impairment. He has an NIH-funded study to determine if red blood cell markers are involved in how RIC works and if they can predict stroke outcomes. He serves as the Associate Editor of the journals Conditioning Medicine and Translational Stroke Research.

A passionate educator of students, residents and fellows, he has received numerous teaching honors including the MCG Educator of the Year Award and multiple Exemplary Teaching Awards. In 2012, he received MCG’s Outstanding Faculty Member Award and the Distinguished Research Award from the university’s Research Institute. In 2001, he received the Humanism in Medicine Award from The Healthcare Foundation of New Jersey and was inducted into the Gold Humanism Honor Society. In 2020, he was honored with the MCG Faculty Senate Spirit of MCG award. Dr. Hess has been named to America’s Top Doctors and Best Doctors in America every year since 2000.

Contact Us

MCG Dean's Office

 Health Sciences Campus

G. Lombard Kelly Building

706-721-2231

MCG Dean

1459 Laney Walker Boulevard, Augusta, GA 30912

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Dr. David Hess' Research

Publication
​

Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial

Morais, A., Imai, T., Jin, X., Locascio, J. J., Boisserand, L., Herman, A. L., Chauhan, A., Lamb, J., Nagarkatti, K., Diniz, M. A., Kumskova, M., Dhanesha, N., Kamat, P. K., Khan, M. B., Dhandapani, K. M., Patel, R. B., Sutariya, B., Shi, Y., van Leyen, K. & Kimberly, W. T. & 8 others, Hess, D. C., Aronowski, J., Leira, E. C., Koehler, R. C., Chauhan, A. K., Sansing, L. H., Lyden, P. D. & Ayata, C., Aug 16 2024, In: Circulation research. 135, 5, p. 575-592 18 p.

Research output: Contribution to journal › Article › peer-review

​

Cellular senescence as a key contributor to secondary neurodegeneration in traumatic brain injury and stroke

Huang, Z., Xu, P., Hess, D. C. & Zhang, Q., Dec 2024, In: Translational Neurodegeneration. 13, 1, 61.

Research output: Contribution to journal › Review article › peer-review

​

Effect of Remote Ischemic Conditioning on the Form and Function of Red Blood Cells in Patients With Acute Ischemic Stroke

Blauenfeldt, R. A., Waller, J., Drasbek, K. R., Bech, J. N., Hvas, A.-M., Larsen, J. B., Andersen, M. N., Nielsen, M. C., Kjølhede, M., Kjeldsen, M., Gude, M. F., Khan, M. B., Baban, B., Andersen, G. & Hess, D. C., Jan 30 2025, (E-pub ahead of print) In: Stroke.

Research output: Contribution to journal › Article › peer-review

​

Photobiomodulation: shining a light on depression

Wang, L., Mao, L., Huang, Z., Switzer, J. A., Hess, D. C. & Zhang, Q., 2025, In: Theranostics. 15, 2, p. 362-383 22 p.

Research output: Contribution to journal › Review article › peer-review

​

Time of day dependent reduction in stroke infarct volume by the Reverb agonist SR9009 in mice

Kamat, P. K., Khan, M. B., Siddiqui, S., Hattaway, T. G., Anas, A., Rudic, R. D., Baban, B., Dhandapani, K. M. & Hess, D. C., Feb 2025, In: Experimental Neurology. 384, 115067.

Research output: Contribution to journal › Article › peer-review

​

Boosting Acetylcholine Signaling by Cannabidiol in a Murine Model of Alzheimer’s Disease

Khodadadi, H., Salles, É. L., Naeini, S. E., Bhandari, B., Rogers, H. M., Gouron, J., Meeks, W., Terry, A. V., Pillai, A. R., Yu, J. C., Morgan, J. C., Vaibhav, K., Hess, D. C., Dhandapani, K. M., Wang, L. P. & Baban, B., Nov 2024, In: International journal of molecular sciences. 25, 21, 11764.

Research output: Contribution to journal › Article › peer-review

​

Effect of Remote Ischemic Conditioning in Ischemic Stroke Subtypes: A Post Hoc Subgroup Analysis from the RESIST Trial

Blauenfeldt, R. A., Mortensen, J. K., Hjort, N., Valentin, J. B., Homburg, A. M., Modrau, B., Sandal, B. F., Gude, M. F., Berhndtz, A. B., Johnsen, S. P., Hess, D. C., Simonsen, C. Z. & Andersen, G., Apr 1 2024, In: Stroke. 55, 4, p. 874-879 6 p.

Research output: Contribution to journal › Article › peer-review

​

Allogeneic Stem Cell Therapy for Acute Ischemic Stroke: The Phase 2/3 TREASURE Randomized Clinical Trial

Houkin, K., Osanai, T., Uchiyama, S., Minematsu, K., Taguchi, A., Maruichi, K., Niiya, Y., Asaoka, K., Kuga, Y., Takizawa, K., Haraguchi, K., Yoshimura, S., Kimura, K., Tokunaga, K., Aoyama, A., Ikawa, F., Inenaga, C., Abe, T., Tominaga, A. & Takahashi, S. & 8 others, Kudo, K., Fujimura, M., Sugiyama, T., Ito, M., Kawabori, M., Hess, D. C., Savitz, S. I. & Hirano, T., Feb 12 2024, In: JAMA Neurology. 81, 2, p. 154-162 9 p.

Research output: Contribution to journal › Article › peer-review

​

Remote Ischemic Conditioning with Medical Management or Reperfusion Therapy for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis

Li, Q., Guo, J., Chen, H. S., Blauenfeldt, R. A., Hess, D. C., Pico, F., Khatri, P., Campbell, B. C. V., Feng, X., Abdalkader, M., Saver, J. L., Nogueira, R. G., Jiang, B., Li, B., Yang, M., Sang, H., Yang, Q., Qiu, Z., Dai, Y. & Nguyen, T. N., Mar 8 2024, In: Neurology. 102, 7, e207983.

Research output: Contribution to journal › Article › peer-review

​

The impact of ischemic stroke on bone marrow microenvironment and extracellular vesicles: A study on inflammatory and molecular changes

Patel, S., Khan, M. B., Kumar, S., Vyavahare, S., Mendhe, B., Lee, T. J., Cai, J., Isales, C. M., Liu, Y., Hess, D. C. & Fulzele, S., Sep 2024, In: Experimental Neurology. 379, 114867.

Research output: Contribution to journal › Article › peer-review

​

Correction to: Angiotensin II Type 2 Receptor Agonism Alleviates Progressive Post-stroke Cognitive Impairment in Aged Spontaneously Hypertensive Rats (Translational Stroke Research, (2024), 10.1007/s12975-024-01232-1)

Alshammari, A., Pillai, B., Kamat, P., Jones, T. W., Bosomtwi, A., Khan, M. B., Hess, D. C., Li, W., Somanath, P. R., Sayed, M. A., Ergul, A. & Fagan, S. C., 2024, (Accepted/In press) In: Translational Stroke Research.

Research output: Contribution to journal › Comment/debate › peer-review

​

Altering biomolecular condensates as a potential mechanism that mediates cannabidiol effect on glioblastoma

Wang, L. P., Chagas, P. S., Salles, É. L., Naeini, S. E., Gouron, J., Rogers, H. M., Khodadadi, H., Bhandari, B., Alptekin, A., Qin, X., Vaibhav, K., Costigliola, V., Hess, D. C., Dhandapani, K. M., Arbab, A. S., Rutkowski, M., Yu, J. C. & Baban, B., Jun 2024, In: Medical Oncology. 41, 6, 140.

Research output: Contribution to journal › Article › peer-review

​

Angiotensin II Type 2 Receptor Agonism Alleviates Progressive Post-stroke Cognitive Impairment in Aged Spontaneously Hypertensive Rats

Alshammari, A., Pillai, B., Kamat, P., Jones, T. W., Bosomtwi, A., Khan, M. B., Hess, D. C., Li, W., Somanath, P. R., Ergul, A. & Fagan, S. C., 2024, (Accepted/In press) In: Translational Stroke Research.

Research output: Contribution to journal › Article › peer-review

​

Rheo-Erythrocrine Dysfunction as a Biomarker for Remote Ischemic Conditioning Treatment in Acute Ischemic Stroke: A Pilot Randomized Controlled Trial

Kjølhede, M., Andersen, G., Valentin, J. B., Nielsen, M. C., Andersen, M. N., Khan, M. B., Bech, J. N., Hess, D. C. & Blauenfeldt, R. A., Nov 21 2023, In: Journal of the American Heart Association. 12, 22, e031466.

Research output: Contribution to journal › Letter › peer-review

​

Time Dimension Influences Severity of Stroke and Heightened Immune Response in Mice

Kamat, P. K., Khan, M. B., Siddiqui, S., Williams, D., da Silva Lopes Salles, E., Naeini, S. E., Arbab, A. S., Rudic, D. R., Baban, B., Dhandapani, K. M. & Hess, D. C., 2023, (Accepted/In press) In: Translational Stroke Research.

Research output: Contribution to journal › Article › peer-review

​

Remote Ischemic Conditioning for Acute Stroke: The RESIST Randomized Clinical Trial

Blauenfeldt, R. A., Hjort, N., Valentin, J. B., Homburg, A. M., Modrau, B., Sandal, B. F., Gude, M. F., Hougaard, K. D., Damgaard, D., Poulsen, M., Diedrichsen, T., Schmitz, M. L., Von Weitzel-Mudersbach, P., Christensen, A. A., Figlewski, K., Grove, E. L., Hreiðarsdóttir, M. K., Lassesen, H. M., Wittrock, D. & Mikkelsen, S. & 19 others, Væggemose, U., Juelsgaard, P., Kirkegaard, H., Rostgaard-Knudsen, M., Degn, N., Vestergaard, S. B., Damsbo, A. G., Iversen, A. B., Mortensen, J. K., Petersson, J., Christensen, T., Behrndtz, A. B., Bøtker, H. E., Gaist, D., Fisher, M., Hess, D. C., Johnsen, S. P., Simonsen, C. Z. & Andersen, G., Oct 3 2023, In: JAMA. 330, 13, p. 1236-1246 11 p.

Research output: Contribution to journal › Article › peer-review

​

A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke

Lyden, P. D., Diniz, M. A., Bosetti, F., Lamb, J., Nagarkatti, K. A., Rogatko, A., Kim, S., Cabeen, R. P., Koenig, J. I., Akhter, K., Arbab, A. S., Avery, B. D., Beatty, H. E., Bibic, A., Cao, S., Boisserand, L. S. B., Chamorro, A., Chauhan, A., Diaz-Perez, S. & Dhandapani, K. & 29 others, Dhanesha, N., Goh, A., Herman, A. L., Hyder, F., Imai, T., Johnson, C. W., Khan, M. B., Kamat, P., Karuppagounder, S. S., Kumskova, M., Mihailovic, J. M., Mandeville, J. B., Morais, A., Patel, R. B., Sanganahalli, B. G., Smith, C., Shi, Y., Sutariya, B., Thedens, D., Qin, T., Velazquez, S. E., Aronowski, J., Ayata, C., Chauhan, A. K., Leira, E. C., Hess, D. C., Koehler, R. C., McCullough, L. D. & Sansing, L. H., Sep 20 2023, In: Science Translational Medicine. 15, 714, eadg8656.

Research output: Contribution to journal › Article › peer-review

​

Safety and Tolerability of Direct Ischemic Postconditioning Following Thrombectomy for Acute Ischemic Stroke

Wu, L., Wei, M., Zhang, B., Zhang, B., Chen, J., Wang, S., Luo, L., Liu, S., Li, S., Ren, C., Hess, D. C., Song, H., Zhao, W. & Ji, X., Sep 1 2023, In: Stroke. 54, 9, p. 2442-2445 4 p.

Research output: Contribution to journal › Article › peer-review

​

Remote Ischemic Conditioning: Challenges and Opportunities

Zhao, W., Hausenloy, D. J., Hess, D. C., Yellon, D. M. & Ji, X., Aug 1 2023, In: Stroke. 54, 8, p. 2204-2207 4 p.

Research output: Contribution to journal › Review article › peer-review

​

Inhalant Cannabidiol Inhibits Glioblastoma Progression Through Regulation of Tumor Microenvironment

Khodadadi, H., Salles, É. L., Alptekin, A., Mehrabian, D., Rutkowski, M., Arbab, A. S., Yeudall, W. A., Yu, J. C., Morgan, J. C., Hess, D. C., Vaibhav, K., Dhandapani, K. M. & Baban, B., Oct 1 2023, In: Cannabis and Cannabinoid Research. 8, 5, p. 824-834 11 p.

Research output: Contribution to journal › Article › peer-review

​

NT2N Cell Transplantation and GDNF Treatment in Stroke: Linking Neurotrophic Factor Therapy and Neuroprotection

Borlongan, C. V., Stahl, C. E., Yu, G., Xu, L., Yasuhara, T., Hara, K., Matsukawa, N., Sanberg, P. R., Wang, Y. & Hess, D. C., 2007, Cellular Transplantation. Elsevier Inc., p. 353-371 19 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

​

Chronic remote ischaemic conditioning in patients with symptomatic intracranial atherosclerotic stenosis (the RICA trial): a multicentre, randomised, double-blind sham-controlled trial in China

RICA investigators, Dec 2022, In: The Lancet Neurology. 21, 12, p. 1089-1098 10 p.

Research output: Contribution to journal › Article › peer-review

​

Inhalant cannabidiol impedes tumor growth through decreased tumor stemness and impaired angiogenic switch in NCI-H1437-induced human lung cancer model

Salles, É. L., Naeini, S. E., Khodadadi, H., Bhandari, B., Rezaee, S., Threlkeld, E., Rogers, H. M., Costigliola, V., Terry, A. V., Hess, D. C., Deb, S., Deb, S. P., Yeudall, W. A., Yu, J. C., Wang, L. P. & Baban, B., May 2023, In: Human Cell. 36, 3, p. 1204-1210 7 p.

Research output: Contribution to journal › Article › peer-review

​

A potential role for cannabichromene in modulating TRP channels during acute respiratory distress syndrome

Khodadadi, H., Salles, É. L., Shin, E., Jarrahi, A., Costigliola, V., Kumar, P., Yu, J. C., Morgan, J. C., Hess, D. C., Vaibhav, K., Dhandapani, K. M. & Baban, B., Dec 2021, In: Journal of Cannabis Research. 3, 1, 45.

Research output: Contribution to journal › Article › peer-review

​

Exercise Improves Cerebral Blood Flow and Functional Outcomes in an Experimental Mouse Model of Vascular Cognitive Impairment and Dementia (VCID)

Khan, M. B., Alam, H., Siddiqui, S., Shaikh, M. F., Sharma, A., Rehman, A., Baban, B., Arbab, A. S. & Hess, D. C., Apr 2024, In: Translational Stroke Research. 15, 2, p. 446-461 16 p.

Research output: Contribution to journal › Article › peer-review

​

Altered endocannabinoid metabolism compromises the brain-CSF barrier and exacerbates chronic deficits after traumatic brain injury in mice

Ahluwalia, M., Mcmichael, H., Kumar, M., Espinosa, M. P., Bosomtwi, A., Lu, Y., Khodadadi, H., Jarrahi, A., Khan, M. B., Hess, D. C., Rahimi, S. Y., Vender, J. R., Vale, F. L., Braun, M., Baban, B., Dhandapani, K. M. & Vaibhav, K., Mar 2023, In: Experimental Neurology. 361, 114320.

Research output: Contribution to journal › Article › peer-review

​

The time dimension to stroke: Circadian effects on stroke outcomes and mechanisms

Kamat, P. K., Khan, M. B., Smith, C., Siddiqui, S., Baban, B., Dhandapani, K. & Hess, D. C., Jan 2023, In: Neurochemistry International. 162, 105457.

Research output: Contribution to journal › Article › peer-review

​

Editorial: Remote Ischemic Conditioning (Pre, Per, and Post) as an Emerging Strategy of Neuroprotection in Ischemic Stroke

Purroy, F., Beretta, S., England, T. J., Hess, D. C., Pico, F. & Shuaib, A., Jun 23 2022, In: Frontiers in Neurology. 13, 932891.

Research output: Contribution to journal › Editorial › peer-review

​

Remote Ischemic Conditioning: Feasible and Potentially Beneficial for Ischemic Stroke

Hess, D. C., Blauenfeldt, R. A. & Andersen, G., Aug 16 2022, In: JAMA. 328, 7, p. 622-624 3 p.

Research output: Contribution to journal › Comment/debate › peer-review

​

Neuropsychiatric sequelae of long COVID-19: Pilot results from the COVID-19 neurological and molecular prospective cohort study in Georgia, USA

Chen, A. K., Wang, X., McCluskey, L. P., Morgan, J. C., Switzer, J. A., Mehta, R., Tingen, M., Su, S., Harris, R. A., Hess, D. C. & Rutkowski, E. K., Oct 2022, In: Brain, Behavior, and Immunity - Health. 24, 100491.

Research output: Contribution to journal › Article › peer-review

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