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  • Dong-oh Seo, PhD

Dong-oh Seo, PhD

Dong oh Seo, PhD

Assistant Professor

Dept. of Neuroscience & Regenerative Medicine

Mailing Address:

Dept. of Neuroscience & Regenerative Medicine
1120 15th Street, Rm. CA-4016
Medical College of Georgia at Augusta University
Augusta, GA 30912

icon Phone:   (706) 721-7851
icon Office: CA-4016
icon E-mail:   dseo@augusta.edu

Education:

2015 - Ph.D. in Behavioral Neuroscience, The University of Texas at Austin, TX

Training:

2015-2020 Postdoctoral Research Associate, Washington University in St. Louis, MO 

2015-2025 Instructor, Washington University in St. Louis, MO 

 

Research Interests

My research program lies in psychoneuroimmunology. Currently, my laboratory broadly focuses on the impact of the gut microbiome on Alzheimer’s disease (AD) development, as well as the interactions between neuropsychiatric symptoms and AD pathology. 

AD is a fatal, progressive neurodegenerative disorder characterized by the early deposition of amyloid-β (Aβ) plaques, followed by pathological tau accumulation in the brain. Despite tremendous research efforts to understand this complex disease—which is influenced by multiple genetic, environmental, and lifestyle factors—its exact pathophysiology remains unclear, and no effective treatments are currently available. 

The multifaceted nature of AD highlights the need for a comprehensive and multidimensional approach. Two distinct but potentially interconnected risk factors have recently garnered interest as regulators of AD pathology: (1) an unbalanced gut microbiome and (2) neuropsychiatric status. Although studies have suggested associations between these factors and AD, further research is needed to fully understand their mechanistic roles and to translate these findings into clinical applications. To investigate these complex interactions, we utilize genetically engineered mouse models and advanced, high-resolution neuroscience techniques—including multi-omics data analyses, optogenetic manipulation and monitoring—combined with neuropathological, biochemical, and behavioral analyses. 

Recent Publications

  1. Seo DO, O'Donnell D, Jain N, Ulrich JD, Herz J, Li Y, Lemieux M, Cheng J, Hu H, Serrano JR, Bao X, Franke E, Karlsson M, Meier M, Deng S, Desai C, Dodiya H, Lelwala-Guruge J, Handley SA, Kipnis J, Sisodia SS, Gordon JI, Holtzman DM. (2023). ApoE isoform and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy. Science, 379, 6628. Highlighted by Science and Nature Commentaries: by Jain & Li (Science), Martín-Peña & Tansey (Nature), Kazmi & Hsiao (Cell), Yates (Nature Review Neuroscience). 
  2. Seo DO, Zhang ET, Piantadosi SC, Marcus DJ, Motard LE, Kan BK, Gomez AM, Nguyen TK, Xia Li, Bruchas MR. (2021). Locus coeruleus to dentate gyrus noradrenergic circuit modulates aversive contextual processing. Neuron,109(13):2116-2130. 
  3. Seo DO, Carillo MA, Chih-Hsiung Lim, S, Tanaka KF, Drew MR (2015). Adult Hippocampal Neurogenesis Modulates Fear Learning through Associative and Nonassociative Mechanisms. Journal of Neuroscience, 35(32), 11330-11345. 

Great Doctors, Great Medicine Since 1828. 

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