David Wolff, PhD
Assistant Professor
Dr. David Wolff received a PhD in Cancer Biology from Roswell Park Comprehensive Cancer Institute in Buffalo, NY in 2017. He received postdoctoral training at Wake Forest University in Winston-Salem, NC, and at Duke University in Durham, NC. Dr. Wolff also worked as a visiting researcher at the University of North Carolina in Chapel Hill, NC. During his postdoctoral studies, he contributed to our understanding of how GTP production is spatially regulated in cancer, and how this regulation contributes to cancer cell invasion. The Wolff laboratory focuses on further understanding the role of GTP synthesis in promoting cancer progression and metastasis, and utilizes fluorescent intracellular probes to study how the intracellular architecture of GTP metabolism influences cancer cell phenotypes.
The David Wolff Lab
Health Sciences Campus
Georgia Cancer Center - M. Bert Storey Research Building
1410 Laney Walker Blvd., CN-2125, Augusta, GA 30912
Primary Areas of Interest: biochemistry, molecular biology, cancer biology
Cancer Diseases of Interest: melanoma
Other Diseases of Interest
Research Methodologies: fluorescence microscopy, animal tumor models, mammalian cell culture
Current Research Project(s)/Grant(s): Interrogating the role of GTP metabolism in Rac1-driven phenotypes in melanoma (NCI K99/R00)
Regulation of local GTP availability controls RAC1 activity and cell invasion. Anna Bianchi-Smiraglia, David W Wolff, Daniel J Marston, Zhiyong Deng, Zhannan Han, Sudha Moparthy, Rebecca M Wombacher, Ashley L Mussell, Shichen Shen, Jialin Chen, Dong-Hyun Yun, Anderson O'Brien Cox, Cristina M Furdui, Edward Hurley, Maria Laura Feltri, Jun Qu, Thomas Hollis, Jules Berlin Nde Kengne, Bernard Fongang, Rui J Sousa, Mikhail E Kandel, Eugene S Kandel, Klaus M Hahn, Mikhail A Nikiforov. Nat Commun. 2021 Oct 19;12(1):6091. doi: 10.1038/s41467-021-26324-6. PMID: 34667203
Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4. David W Wolff, Zhiyong Deng, Anna Bianchi-Smiraglia, Colleen E Foley, Zhannan Han, Xingyou Wang, Shichen Shen, Masha M Rosenberg, Sudha Moparthy, Dong Hyun Yun, Jialin Chen, Brian K Baker, Matthew V Roll, Andrew J Magiera, Jun Li, Edward Hurley, Maria Laura Feltri, Anderson O Cox, Jingyun Lee, Cristina M Furdui, Liang Liu, Wiam Bshara, Leslie E W LaConte, Eugene S Kandel, Elena B Pasquale, Jun Qu, Lizbeth Hedstrom, Mikhail A Nikiforov. Cell Chem Biol. 2022 Jun 16;29(6):970-984.e6. doi: 10.1016/j.chembiol.2022.01.007. PMID: 35148834
Compartmentalization and regulation of GTP in control of cellular phenotypes. David W Wolff, Anna Bianchi-Smiraglia, Mikhail A Nikiforov. Review. Trends Mol Med. 2022 Sep;28(9):758-769. doi: 10.1016/j.molmed.2022.05.012. PMID: 35718686
