 |
Carl Sanders Research and Education Building, CB2601
Office phone icon: 706-443-4138
Lab phone icon: 706-446-0019
Members of the Lab |
Dr. Raju's laboratory is focused on the study of molecular basis of organ function changes following injury and influence of aging using a multidisciplinary approach. His research utilizes both in vivo and in vitro models. In one of the major projects in his laboratory, he investigates mitochondrial alterations and immune regulation following hemorrhagic shock. His laboratory has identified age-associated changes in mitochondrial gene expression following hemorrhagic shock and has found SIRT1 as a potential target. The sirtuin family of proteins is associated with longevity and regulates mitochondrial biogenesis factors. His continued studies demonstrate a key role for mitochondria in the outcome following hemorrhagic shock. His research led to the identification of several small molecules in improving organ function and survival following hemorrhagic shock in rodent models. Mitochondrial dysfunction is a common denominator for both aging and injury. His laboratory uses a number of genetically modified mouse models to understand the regulation of mitochondrial function in aging and injury. His research group is also interested in understanding how mitochondria regulate inflammation. His long term goal is to understand the role of cellular energetics and the influence of aging in the outcome following injury. Dr. Raju has authored over 70 peer-reviewed articles, and his research is currently funded by the National Institutes of Health.
2000 Research Associate Mayo Clinic, Rochester, MN
1995 Postoctoral Training University of Minnesota, St Paul, MN
1993 PhD All India Institute of Medical Sciences, New Delhi
2013 - Present Professor, Augusta University, Augusta, GA
2007 - 2013 Associate Professor, University of Alabama at Birmingham, Birmingham, AL
2001 - 2007 Senior Staff Fellow, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
2014 - present BBA - Molecular Basis of Disease
2013 - present PLOS ONE, Academic Editor
2010 - present Aging and Disease
2017 Guest Editor: BBA Mol Basis of Dis
2014 Guest Editor: Aging and Injury (Special Issue of Aging and Disease)
2006 - 2010 Journal of Immunology, Associate Editor
Frontiers in Intensive Care Medicine and Anesthesiology
Dr. Raju has served on several grant review panels including study sections of the National Institutes of Health, Department of Veterans Affairs, Department of Defense, and American Heart Association. Dr. Raju has also served on an NIH study section as a Chartered member.
Lavarti R, Cai L, Alvarez-Diaz, Rodriguez TM, Bombin S and Raju RP. Senescence landscape in the liver following sepsis and senolytics as potential therapeutics. Aging cell, 2024 (in press).
Kar P, Sivasailam A, Lavarti R, Cai L, Thangaraju M, Nguyen, E, Mundluru B and Raju RP. p53 dependence of senescence markers p21v1 and p21v2 in aging and acute injury. NPJ Aging, 2024 (in press).
Schoenmann N, Tannenbaum N, Hodgeman RM, Raju RP. Regulating mitochondrial metabolism by targeting pyruvate dehydrogenase with dichloroacetate, a metabolic messenger. Biochim Biophys Acta Mol Basis Dis. 2023 Oct;1869(7):166769.
Cai L, Arbab AS, Lee TJ, Sharma A, Thomas B, Igarashi K, Raju RP. BACH1-Hemoxygenase-1 axis regulates cellular energetics and survival following sepsis. Free Radic Biol Med. 2022 Jun 9;188:134-145.