Jie Li
Assistant Professor
Academic Appointment(s)
Medical College of Georgia
Department of Pharmacology and Toxicology
Medical College of Georgia
Department of Medicine: Cardiology
The Graduate School
Bio
Jie Li is currently Assistant Professor at the Vascular Biology Center. Her research interest is to understand how to prevent and treat heart failure.
- (706) 721-9414
- (706) 721-9799
- CB-3717
Education
Awards & Honors
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Junior faculty award, 1st place
ACRE-APS Research Symposium, 2020
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New Investigator Travel Award of the Basic Cardiovascular Sciences Conference
American Heart Association, 2011
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Poster Award of the Protein Quality Control Symposium
University of South Dakota, 2011
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University of South Dakota Graduate Research Grant
University of South Dakota, 2005
Courses Taught Most Recent Academic Year
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BIOM 8040
Intro to Faculty Research
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BIOM 8050
Intro to Research I
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VBIO 8010
Methods in Cardiovascular Rese
Teaching Interests
Jie Li is dedicated to fostering the next generation of scientists in the classroom and laboratory setting and also involved in teaching graduate and medical students a number of different courses.
Scholarship
Selected Recent Publications
- TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes., 2021
Journal Article, Academic Journal
- Adenosine kinase inhibition enhances microvascular dilator function and improves left ventricle diastolic dysfunction., 2020
Journal Article, Academic Journal
- COP9 Signalosome Suppresses RIPK1-RIPK3-Mediated Cardiomyocyte Necroptosis in Mice., 2020
Journal Article, Academic Journal
- The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction., 2020
Journal Article, Academic Journal
- Transient inhibition of neddylation at neonatal stage evokes reversible cardiomyopathy and predisposes the heart to isoproterenol-induced heart failure., 2019
Journal Article, Academic Journal
Research Interests
Maintenance of a functional proteome is integral to cardiomyocyte function and survival. Ubiquitin (Ub) and ubiquitin-like (Ubl) proteins are crucial regulators of protein quality and function through post-translational modification of their diverse substrates. To date, how Ub and Ubl-mediated PTMs control the function and survival of cardiomyocytes, or how dysregulation of such PTMs contributes to the development of cardiomyopathy and heart failure, remains poorly understood. My research aims to understand the molecular basis by which Ub and Ubls regulate the structure and function of cardiac muscle tissue, and ultimately to uncover novel therapeutic targets and strategies to prevent and treat cardiac disease.
