Jie Li
Assistant Professor
Academic Appointment(s)
Medical College of Georgia
Department of Pharmacology and Toxicology
Medical College of Georgia
Department of Medicine: Cardiology
The Graduate School
Bio
Jie Li is currently Assistant Professor at the Vascular Biology Center. Her research interest is to understand how to prevent and treat heart failure.
Education
Awards & Honors
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Junior faculty award, 1st place
ACRE-APS Research Symposium, 2020
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New Investigator Travel Award of the Basic Cardiovascular Sciences Conference
American Heart Association, 2011
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Poster Award of the Protein Quality Control Symposium
University of South Dakota, 2011
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University of South Dakota Graduate Research Grant
University of South Dakota, 2005
Courses Taught Most Recent Academic Year
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BIOM 8130
Scientific Grant Writing
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VBIO 9210
Investigation of a Prob
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VBIO 9010
Seminar in Vascular Bio
Teaching Interests
Jie Li is dedicated to fostering the next generation of scientists in the classroom and laboratory setting and also involved in teaching graduate and medical students a number of different courses.
Scholarship
Selected Recent Publications
- Neddylation is required for perinatal cardiac development through stimulation of metabolic maturation, 2023
Journal Article, Academic Journal
- BSCL2/Seipin deficiency in hearts causes cardiac energy deficit and dysfunction via inducing excessive lipid catabolism., 2022
Journal Article, Academic Journal
- TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes., 2021
Journal Article, Academic Journal
- Adenosine kinase inhibition enhances microvascular dilator function and improves left ventricle diastolic dysfunction., 2020
Journal Article, Academic Journal
- COP9 Signalosome Suppresses RIPK1-RIPK3-Mediated Cardiomyocyte Necroptosis in Mice., 2020
Journal Article, Academic Journal
Research Interests
Maintenance of a functional proteome is integral to cardiomyocyte function and survival. Ubiquitin (Ub) and ubiquitin-like (Ubl) proteins are crucial regulators of protein quality and function through post-translational modification of their diverse substrates. To date, how Ub and Ubl-mediated PTMs control the function and survival of cardiomyocytes, or how dysregulation of such PTMs contributes to the development of cardiomyopathy and heart failure, remains poorly understood. My research aims to understand the molecular basis by which Ub and Ubls regulate the structure and function of cardiac muscle tissue, and ultimately to uncover novel therapeutic targets and strategies to prevent and treat cardiac disease.
