David Stepp

Charbonnier Chair for Physiology

David Stepp

Charbonnier Chair for Physiology

Professor

Academic Appointment(s)

Medical College of Georgia
Department of Physiology

Medical College of Georgia
Department of Vascular Biology Center

The Graduate School

Other Duties

Director, USG MD-PhD Program, MCG Academic Affairs, Curriculum

  • (706) 721-1949
  • CB 3211B

Education

  • Ph.D., Physiology, General University of Pennsylvania, 1993

  • BS, Biology/Biological Sciences, General University of South Carolina -, 1988

Awards & Honors

  • Outstanding Faculty Award Medical College of Georgia, Augusta University, 2020

  • Exemplary Teaching Award Medical College of Georgia, Augusta University, 2018

  • Exemplary Teaching Award, School of Medicine 2011

  • Virendra Mahesh Distinguished Research Award 2010

Courses Taught Most Recent Academic Year

  • VBIO 9210

    Investigation of a Prob
  • VBIO 9300

    Research in Vascular Bio
  • VBIO 9010

    Seminar in Vascular Bio
  • MEDI 6300

    Career Paths in Med
  • VBIO 8010

    Methods in Cardiovascular Rese
  • BIOM 8011

    Respon Conduct of Research
  • BIOM 8130

    Scientific Grant Writing

Scholarship

Selected Recent Publications

  • Obesity Induces Disruption of Microvascular Endothelial Circadian Rhythm, 2022
    Journal Article, Academic Journal
  • Protective role of Cav-1 in pneumolysin-induced endothelial barrier dysfunction, 2022
    Journal Article, Academic Journal
  • The biological clock enhancer nobiletin ameliorates steatosis in genetically obese mice by restoring aberrant hepatic circadian rhythm, 2022
    Journal Article, Academic Journal
  • Nf1 heterozygous mice recapitulate the anthropometric and metabolic features of human neurofibromatosis type 1, 2021
    Journal Article, Academic Journal
  • Obesity and the Bidirectional Risk of Cancer and Cardiovascular Diseases in African Americans: Disparity vs. Ancestry, 2021
    Other

Research Interests

Work in our lab is devoted to unraveling links between obesity and cardiometabolic dysfunction. While weight loss is ideal, the overwhelming majority of the obese population – either due to chronic entrainment of metabolism or behavior, increased age or accumulation of injuries – retain or regain excess weight. A critical need therefore is to break the links between obesity and its cardiovascular outcomes. The CORE HYPOTHESIS of our laboratory is that resolution of endocrine and metabolic abnormalities in obesity is the path to preventing cardiovascular disease in overweight patients. Currently, the central theme of these studies is that the balance of nitric oxide (NO) derived from eNOS and the loss of its bioavailability from NADPH Oxidase (NOX)-generated super-oxide is a key determinant of cardiometabolic health. Changes in glycemic status, either absolute levels or pattern of hyperglycemia, appear to be a primary determinant of states in which super-oxide excess reduces NO below a threshold needed for full cardiovascular function. Thus, the glucose-NOS/NOX axis in the primary focus of studies in our lab.

Professional Service

  • Atherosclerosis, Thrombosis and Vascular Biology 2010 - Present

    Role: Editorial Review Board Member
  • Basic Research in Cardiology 2010 - Present

    Role: Editorial Review Board Member
  • Frontiers in Oxidant Physiology 2010 - Present

    Role: Editorial Review Board Member
  • Circulation Research 2009 - Present

    Role: Editorial Review Board Member
  • American Journal of Physiology (Regulatory) 2007 - Present

    Role: Editorial Review Board Member