Ali Arbab
Professor
Academic Appointment(s)
Medical College of Georgia
Department of Biochemistry and Molecular Biology
Medical College of Georgia
Department of Georgia Cancer Center
The Graduate School
Administration
Department of The Graduate School
Bio
I have 33 years of experience in imaging science, involving MRI, SPECT, CT, ultrasound, and optical imaging modalities. My laboratory is working on targeting the tumor microenvironment of GBM and breast cancers using different engineered exosomes and drug-loaded nanocapsules.
Education
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Ph.D., Medical Scientist.
Yamanashi Medical University, 1998
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MD, Medicine
University of Dhaka, 1988
Awards & Honors
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Grant Reviewer
The National Institutes of Health, 2020
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Grant reviewer
California Institute of Regenerative Medicine, 2017
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Travel Award
Radiological Society of North America (RSNA), 2008
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Fellows Award for Research Excellence (FARE)
The National Institutes of Health, 2003
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Asia-Oceania Young Investigator’s Award
Japanese Society of Nuclear Medicine, 1999
Courses Taught Most Recent Academic Year
Teaching Interests
Tumor neovascularization.
Biomedical Imaging
Tumor microenvironment and possible effect after chemotherapy
Scholarship
Selected Recent Publications
- Pulsed Focal Ultrasound as a Non-Invasive Method to Deliver Exosomes in the Brain/Stroke., 2021
Journal Article, Academic Journal
- Proteomic Characterization, Biodistribution, and Functional Studies of Immune-Therapeutic Exosomes: Implications for Inflammatory Lung Diseases., 2021
Journal Article, Academic Journal
- Critical immunosuppressive effect of MDSC‑derived exosomes in the tumor microenvironment., 2021
Journal Article, Academic Journal
- Changes in the tumor microenvironment and outcome for TME-targeting therapy in glioblastoma: A pilot study., 2021
Journal Article, Academic Journal
- Stroke promotes the development of brain atrophy and delayed cell death in hypertensive rats., 2020
Journal Article, Academic Journal
Research Interests
> Generation of engineered exosomes to initiate ADCC of targeted cells by NK cells.
> Generation of engineered exosomes to target dying neurons in stroke
> Ultrasound-mediated delivery of exosomes to the stroke area to enhance the better outcome
> Understanding the mechanisms of resistance to antiangiogenic treatment in solid tumors.
> Targeting arachidonic acid metabolites for the treatment of solid tumors.
>Tumor cell-secreted exosomes in modulating tumor microenvironment and niche for distal metastasis.
> Generation of tissue-specific MRI and SPECT contrast agents and drug delivery systems (nanoparticles).
> Understand the mechanisms of GVHD to delay it by targeting myeloid cells.
Department Service
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Director 3T human MRI core
2023 - Present
Role: Other
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GCC proteomics core
2021 - Present
Role: Committee Member
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Small animal core advisory committee
2021 - Present
Role: Committee Member
University Service
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PT committee of DCG
2023 - Present
Role: Committee Member
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ARAC
2021 - Present
Role: Committee Member
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Mock Study Section
2019 - 2020
Role: Administrative Assignment, Other
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Steering Committee
2019 - 2020
Role: Committee Member
Professional Service
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NIH study panel
2016 - Present
Role: Reviewer, Grant Proposal
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CIRM
2004 - Present
Role: Member
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Scientific Journals
- 2020
Role: Reviewer
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Various scientific journals
- 2020
Role: Editorial Review Board Member
