Carlos M. Isales, MD

Regents' Professor

Dept. of Neuroscience & Regenerative Medicine

J. Harold Harrison Distinguished University Chair in Healthy Aging

Chief, Division of Endocrinology & Metabolism

Clinical Director Center for Healthy Aging

Mailing Address:

Dept. of Neuroscience & Regenerative Medicine
1120 15th Street, Rm. CA1004
Medical College of Georgia at Augusta University
Augusta, GA 30912

Office Phone:  (706) 721-0692
Email:  cisales@augusta.edu

Education and Training:

University of Puerto Rico School of Medicine
San Juan VA Hospital- Internal Medicine
Yale School of Medicine- Endocrinology and Metabolism 

Research interests:

Epigenetic changes induced by aging and their impact on mesenchymal stem cell function and tissue regeneration.

Current projects:

2P01AG036675-06A1 - (PI) - National Institutes of Health/National Institutes on Aging, "Age-induced Impairment of Nutrient Signaling Results in Bone Loss"                           

Lab members:

Qing Zhong, MD
Ke-Hong Ding, MD, PhD
Baolin Kang, PhD
Debra Irsik, PhD
Roger Zhong
Jianrui Xu

 Selected publications:

1. Kim BJ, Hamrick MW, Yoo HJ, Lee SH, Kim SJ, Koh JM, Isales CM. 2019, The Detrimental Effects of Kynurenine, a Tryptophan Metabolite, on Human Bone Metabolism. J Clin Endocrinol Metab;104(6):2334-42. Epub 2019/02/05. doi: 10.1210/jc.2018-02481. PubMed PMID: 30715395; PubMed Central PMCID: PMCPMC6497841.
2. Ding KH, Cain M, Davis M, Bergson C, McGee-Lawrence M, Perkins C, Hardigan T, Shi X, Zhong Q, Xu J, Bollag WB, Hill W, Elsalanty M, Hunter M, Isales MC, Lopez P, Hamrick M, Isales CM. 2018, Amino acids as signaling molecules modulating bone turnover. Bone;115:15-24. Epub 2018/03/03. doi: 10.1016/j.bone.2018.02.028. PubMed PMID: 29499416; PubMed Central PMCID: PMCPMC6110952.
3. Ramsey W, Isales CM. 2017, Intestinal Incretins and the Regulation of Bone Physiology. Adv Exp Med Biol;1033:13-33. Epub 2017/11/05. doi: 10.1007/978-3-319-66653-2_2. PubMed PMID: 29101649.
4. Refaey ME, McGee-Lawrence ME, Fulzele S, Kennedy EJ, Bollag WB, Elsalanty M, Zhong Q, Ding KH, Bendzunas NG, Shi XM, Xu J, Hill WD, Johnson MH, Hunter M, Pierce JL, Yu K, Hamrick MW, Isales CM. 2017, Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss. J Bone Miner Res;32(11):2182-93. Epub 2017/07/21. doi: 10.1002/jbmr.3224. PubMed PMID: 28727234; PubMed Central PMCID: PMCPMC5685888.
5. MacDonell R, Hamrick MW, Isales CM. 2016, Protein/amino-acid modulation of bone cell function. Bonekey Rep;5:827. Epub 2017/02/06. doi: 10.1038/bonekey.2016.58. PubMed PMID: 28149508; PubMed Central PMCID: PMCPMC5238414.
6. El Refaey M, Watkins CP, Kennedy EJ, Chang A, Zhong Q, Ding KH, Shi XM, Xu J, Bollag WB, Hill WD, Johnson M, Hunter M, Hamrick MW, Isales CM. 2015, Oxidation of the aromatic amino acids tryptophan and tyrosine disrupts their anabolic effects on bone marrow mesenchymal stem cells. Mol Cell Endocrinol;410:87-96. Epub 2015/02/01. doi: 10.1016/j.mce.2015.01.034. PubMed PMID: 25637715; PubMed Central PMCID: PMCPMC4444384.
7. El Refaey M, Zhong Q, Hill WD, Shi XM, Hamrick MW, Bailey L, Johnson M, Xu J, Bollag WB, Chutkan N, Isales CM. 2014, Aromatic amino acid activation of signaling pathways in bone marrow mesenchymal stem cells depends on oxygen tension. PLoS One;9(4):e91108. Epub 2014/04/15. doi: 10.1371/journal.pone.0091108. PubMed PMID: 24727733; PubMed Central PMCID: PMCPMC3984069.
8. Isales CM, Zaidi M, Blair HC. 2010, ACTH is a novel regulator of bone mass. Ann N Y Acad Sci;1192:110-6. Epub 2010/04/16. doi: 10.1111/j.1749-6632.2009.05231.x. PubMed PMID: 20392225.
9. Isales CM, Hamrick M. 2008, Nutritional hormones and the entero-osseous axis. J Musculoskelet Neuronal Interact;8(4):348-50. Epub 2009/01/17. PubMed PMID: 19147971.
10. Blair HC, Wells A, Isales CM. 2007, Pituitary glycoprotein hormone receptors in non-endocrine organs. Trends Endocrinol Metab;18(6):227-33. Epub 2007/06/26. doi: 10.1016/j.tem.2007.06.001. PubMed PMID: 17588768.
11. Xie D, Zhong Q, Ding KH, Cheng H, Williams S, Correa D, Bollag WB, Bollag RJ, Insogna K, Troiano N, Coady C, Hamrick M, Isales CM. 2007, Glucose-dependent insulinotropic peptide-overexpressing transgenic mice have increased bone mass. Bone;40(5):1352-60. Epub 2007/02/27. doi: 10.1016/j.bone.2007.01.007. PubMed PMID: 17321229.
12. Zhong Q, Itokawa T, Sridhar S, Ding KH, Xie D, Kang B, Bollag WB, Bollag RJ, Hamrick M, Insogna K, Isales CM. 2007, Effects of glucose-dependent insulinotropic peptide on osteoclast function. Am J Physiol Endocrinol Metab;292(2):E543-8. Epub 2006/09/28. doi: 10.1152/ajpendo.00364.2006. PubMed PMID: 17003233.
13. Xie D, Cheng H, Hamrick M, Zhong Q, Ding KH, Correa D, Williams S, Mulloy A, Bollag W, Bollag RJ, Runner RR, McPherson JC, Insogna K, Isales CM. 2005, Glucose-dependent insulinotropic polypeptide receptor knockout mice have altered bone turnover. Bone;37(6):759-69. Epub 2005/10/13. doi: 10.1016/j.bone.2005.06.021. PubMed PMID: 16219496.
14. Zhong Q, Sridhar S, Ruan L, Ding KH, Xie D, Insogna K, Kang B, Xu J, Bollag RJ, Isales CM. 2005, Multiple melanocortin receptors are expressed in bone cells. Bone;36(5):820-31. Epub 2005/04/05. doi: 10.1016/j.bone.2005.01.020. PubMed PMID: 15804492.