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- Randomized Pilot Trial of Whole-Body Vibration in Lowering the Atherosclerotic Chemokine Level in Prostate Cancer Participants on Androgen Deprivation Therapy with Clonal Hematopoiesis
Clinical Trial
Randomized Pilot Trial of Whole-Body Vibration in Lowering the Atherosclerotic Chemokine Level in Prostate Cancer Participants on Androgen Deprivation Therapy with Clonal Hematopoiesis
This study will be performed in prostate cancer patients who are undergoing hormone therapy and have certain genetic changes. We aim to find out if using a whole-body vibration machine can lower the levels of certain substances in the blood that are linked to heart disease and also make the blood vessels less stiff over three months. We will also see how this study may improve your quality of life. This study will go on for 3 months.
Eligibility Criteria
- Inclusion Criteria - You need to willingly sign a consent form if you are a male, 18 years or older, with good enough cognitive function to participate in questionnaires and other study activities. - You must have a diagnosis of a certain type of prostate cancer (adenocarcinoma, Stage 1 to Stage 4A) and be receiving hormone therapy for it. - You should have a specific genetic change (CHIP mutation in TET2 or DNMT3A genes) and not have uncontrolled chronic diseases like diabetes, high blood pressure, or thyroid problems. - You cannot have lost 10% or more of your weight without trying in the last 6 months and should be doing less than 60 minutes of structured exercise per week. - Your blood level of hemoglobin must be stable (?8 g/dL) within 2 weeks of joining, and you should not have any active infections. - You must be fluent in English to understand and sign the written consent document. Exclusion Criteria - You have Metastases to brain or Stage 4B Prostate Cancer per clinical evaluation. - You have major physical limitations or contraindications to exercise.
RESEARCH. INNOVATION. DISCOVERY.