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This is a research study to test a new drug called roxadustat (also known as FG-4592) that is not approved by the Food and Drug Administration (FDA) to treat anemia (not enough red blood cells) in people diagnosed with lower risk myelodysplastic syndrome (MDS) (a rare disorder in which your bone marrow does not make enough healthy blood cells). We are looking to test the safety of the study drug, how much of the study drug is in your body based on what dose you get, how the study drug works on your cancer, and to find the appropriate dose of this study drug to use in this and other future studies.